OCRL

OCRL inositol polyphosphate-5-phosphatase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
in utero embryonic development [GO:0001701],
lipid metabolic process [GO:0006629],
phosphatidylinositol biosynthetic process [GO:0006661],
signal transduction [GO:0007165],
regulation of GTPase activity [GO:0043087],
positive regulation of GTPase activity [GO:0043547],
inositol phosphate metabolic process [GO:0043647],
inositol phosphate dephosphorylation [GO:0046855],
phosphatidylinositol dephosphorylation [GO:0046856],
regulation of small GTPase mediated signal transduction [GO:0051056],
cilium assembly [GO:0060271],
membrane organization [GO:0061024],
cell projection organization [GO:0030030],

Molecular Function:
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439],
inositol-polyphosphate 5-phosphatase activity [GO:0004445],
GTPase activator activity [GO:0005096],
protein binding [GO:0005515],
Rac GTPase binding [GO:0048365],
inositol-1,4,5-trisphosphate 5-phosphatase activity [GO:0052658],
inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity [GO:0052659],
inositol phosphate phosphatase activity [GO:0052745],
hydrolase activity [GO:0016787],

Cellular Component:
photoreceptor outer segment [GO:0001750],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
lysosome [GO:0005764],
early endosome [GO:0005769],
Golgi stack [GO:0005795],
Golgi-associated vesicle [GO:0005798],
trans-Golgi network [GO:0005802],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
clathrin-coated pit [GO:0005905],
membrane [GO:0016020],
clathrin-coated vesicle [GO:0030136],
phagocytic vesicle membrane [GO:0030670],
early endosome membrane [GO:0031901],
endosome [GO:0005768],
Golgi apparatus [GO:0005794],
cilium [GO:0005929],
cytoplasmic vesicle [GO:0031410],
cell projection [GO:0042995],