obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2 Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
protein phosphorylation [GO:0006468],
G-protein coupled receptor signaling pathway [GO:0007186],
multicellular organism development [GO:0007275],
protein localization to M-band [GO:0036309],
positive regulation of apoptotic process [GO:0043065],
sarcomere organization [GO:0045214],
regulation of small GTPase mediated signal transduction [GO:0051056],
negative regulation of phosphatidylinositol 3-kinase signaling [GO:0014067],
phosphorylation [GO:0016310],
cell differentiation [GO:0030154],
regulation of Rho protein signal transduction [GO:0035023],
protein autophosphorylation [GO:0046777],

Molecular Function:
protein serine/threonine kinase activity [GO:0004674],
guanyl-nucleotide exchange factor activity [GO:0005085],
protein binding [GO:0005515],
calmodulin binding [GO:0005516],
ATP binding [GO:0005524],
phosphatidylinositol-4,5-bisphosphate binding [GO:0005546],
phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547],
structural constituent of muscle [GO:0008307],
phosphatidylinositol-5-phosphate binding [GO:0010314],
ankyrin binding [GO:0030506],
titin binding [GO:0031432],
phosphatidylinositol-3-phosphate binding [GO:0032266],
phosphatidylinositol-3,4-bisphosphate binding [GO:0043325],
metal ion binding [GO:0046872],
phosphatidylinositol-4-phosphate binding [GO:0070273],
nucleotide binding [GO:0000166],
protein kinase activity [GO:0004672],
Rho guanyl-nucleotide exchange factor activity [GO:0005089],
lipid binding [GO:0008289],
kinase activity [GO:0016301],
transferase activity [GO:0016740],
cadherin binding [GO:0045296],
phosphatidylinositol bisphosphate binding [GO:1902936],

Cellular Component:
cytosol [GO:0005829],
plasma membrane [GO:0005886],
nuclear body [GO:0016604],
myofibril [GO:0030016],
Z disc [GO:0030018],
M band [GO:0031430],
sarcolemma [GO:0042383],
extracellular region [GO:0005576],
extracellular space [GO:0005615],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
striated muscle myosin thick filament [GO:0005863],
intercalated disc [GO:0014704],
membrane [GO:0016020],
sarcomere [GO:0030017],