ATG5

autophagy related 5

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
21816217 WI-38 Human NO
24027027 WM-451-Lu, Me-260, A-375, A-2058, SK-Mel 1, SK-Mel 2, G-361 Human NO
25144556 MRC-5, WI-38 Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
25341032 MEFs Mouse NO
30894058 RAW 264.7 Mouse NO
31615473 JEG-3, JAR Human NO

GO terms:

Biological Process:
autophagosome assembly [GO:0000045],
mitophagy [GO:0000422],
blood vessel remodeling [GO:0001974],
regulation of cytokine production involved in immune response [GO:0002718],
C-terminal protein lipidation [GO:0006501],
autophagy [GO:0006914],
apoptotic process [GO:0006915],
cellular response to nitrogen starvation [GO:0006995],
response to fungus [GO:0009620],
macroautophagy [GO:0016236],
antigen processing and presentation of endogenous antigen [GO:0019883],
negative regulation of protein ubiquitination [GO:0031397],
aggrephagy [GO:0035973],
negative stranded viral RNA replication [GO:0039689],
vasodilation [GO:0042311],
response to drug [GO:0042493],
negative regulation of apoptotic process [GO:0043066],
post-translational protein modification [GO:0043687],
nucleophagy [GO:0044804],
negative thymic T cell selection [GO:0045060],
otolith development [GO:0048840],
negative regulation of phagocytosis [GO:0050765],
regulation of release of sequestered calcium ion into cytosol [GO:0051279],
ventricular cardiac muscle cell development [GO:0055015],
heart contraction [GO:0060047],
negative regulation of cell death [GO:0060548],
protein lipidation involved in autophagosome assembly [GO:0061739],
positive regulation of mucus secretion [GO:0070257],
cellular response to nitrosative stress [GO:0071500],
autophagy of host cells involved in interaction with symbiont [GO:0075044],
regulation of cilium assembly [GO:1902017],
negative regulation of reactive oxygen species metabolic process [GO:2000378],
negative regulation of histone H4-K16 acetylation [GO:2000619],
immune system process [GO:0002376],
cellular response to starvation [GO:0009267],
regulation of reactive oxygen species metabolic process [GO:2000377],

Molecular Function:
protein binding [GO:0005515],

Cellular Component:
cytoplasm [GO:0005737],
autophagosome [GO:0005776],
cytosol [GO:0005829],
axoneme [GO:0005930],
membrane [GO:0016020],
phagocytic vesicle membrane [GO:0030670],
pre-autophagosomal structure membrane [GO:0034045],
Atg12-Atg5-Atg16 complex [GO:0034274],
ER-mitochondrion membrane contact site [GO:0044233],