NTHL1

nth like DNA glycosylase 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES

GO terms:

Biological Process:
base-excision repair, AP site formation [GO:0006285],
nucleotide-excision repair, DNA incision, 5'-to lesion [GO:0006296],
depyrimidination [GO:0045008],
DNA repair [GO:0006281],
base-excision repair [GO:0006284],
cellular response to DNA damage stimulus [GO:0006974],
metabolic process [GO:0008152],

Molecular Function:
oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity [GO:0000703],
double-stranded DNA binding [GO:0003690],
DNA-(apurinic or apyrimidinic site) lyase activity [GO:0003906],
endonuclease activity [GO:0004519],
protein binding [GO:0005515],
oxidized purine nucleobase lesion DNA N-glycosylase activity [GO:0008534],
DNA N-glycosylase activity [GO:0019104],
metal ion binding [GO:0046872],
4 iron, 4 sulfur cluster binding [GO:0051539],
DNA binding [GO:0003677],
catalytic activity [GO:0003824],
hydrolase activity [GO:0016787],
hydrolase activity, acting on glycosyl bonds [GO:0016798],
lyase activity [GO:0016829],
iron-sulfur cluster binding [GO:0051536],

Cellular Component:
nuclear chromatin [GO:0000790],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
mitochondrion [GO:0005739],