NRXN1

neurexin 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30988157 IMR-90 Human YES

GO terms:

Biological Process:
neuron cell-cell adhesion [GO:0007158],
chemical synaptic transmission [GO:0007268],
neurotransmitter secretion [GO:0007269],
axon guidance [GO:0007411],
synapse assembly [GO:0007416],
learning [GO:0007612],
adult behavior [GO:0030534],
social behavior [GO:0035176],
vocal learning [GO:0042297],
neuromuscular process controlling balance [GO:0050885],
positive regulation of synapse assembly [GO:0051965],
positive regulation of synaptic transmission, glutamatergic [GO:0051968],
prepulse inhibition [GO:0060134],
vocalization behavior [GO:0071625],
positive regulation of synapse maturation [GO:0090129],
postsynaptic membrane assembly [GO:0097104],
gephyrin clustering involved in postsynaptic density assembly [GO:0097116],
neuroligin clustering involved in postsynaptic membrane assembly [GO:0097118],
postsynaptic density protein 95 clustering [GO:0097119],
trans-synaptic signaling by endocannabinoid [GO:0099542],
synaptic membrane adhesion [GO:0099560],
positive regulation of excitatory postsynaptic potential [GO:2000463],
regulation of grooming behavior [GO:2000821],
angiogenesis [GO:0001525],
vesicle docking involved in exocytosis [GO:0006904],
cell adhesion [GO:0007155],
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157],
signal transduction [GO:0007165],
positive regulation of gene expression [GO:0010628],
negative regulation of gene expression [GO:0010629],
positive regulation of protein kinase A signaling [GO:0010739],
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339],
cerebellar granule cell differentiation [GO:0021707],
neuron projection development [GO:0031175],
positive regulation of peptidyl-serine phosphorylation [GO:0033138],
protein localization to synapse [GO:0035418],
neuron maturation [GO:0042551],
establishment of protein localization [GO:0045184],
positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743],
filopodium assembly [GO:0046847],
negative regulation of filopodium assembly [GO:0051490],
positive regulation of protein kinase B signaling [GO:0051897],
regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
cellular response to calcium ion [GO:0071277],
protein complex assembly involved in synapse maturation [GO:0090126],
synaptic vesicle clustering [GO:0097091],
presynaptic membrane assembly [GO:0097105],
gamma-aminobutyric acid receptor clustering [GO:0097112],
NMDA glutamate receptor clustering [GO:0097114],
guanylate kinase-associated protein clustering [GO:0097117],
receptor localization to synapse [GO:0097120],
presynapse assembly [GO:0099054],
positive regulation of protein kinase C activity [GO:1900020],
positive regulation of protein localization to plasma membrane [GO:1903078],
regulation of N-methyl-D-aspartate selective glutamate receptor activity [GO:2000310],
regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [GO:2000311],

Molecular Function:
calcium channel regulator activity [GO:0005246],
calcium ion binding [GO:0005509],
protein binding [GO:0005515],
acetylcholine receptor binding [GO:0033130],
signaling receptor activity [GO:0038023],
cell adhesion molecule binding [GO:0050839],
neuroligin family protein binding [GO:0097109],
transmembrane signaling receptor activity [GO:0004888],
receptor binding [GO:0005102],
type 1 fibroblast growth factor receptor binding [GO:0005105],
macromolecular complex binding [GO:0044877],
metal ion binding [GO:0046872],
calcium-dependent protein binding [GO:0048306],

Cellular Component:
nucleolus [GO:0005730],
endoplasmic reticulum [GO:0005783],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
cell surface [GO:0009986],
nuclear membrane [GO:0031965],
vesicle [GO:0031982],
macromolecular complex [GO:0032991],
presynaptic membrane [GO:0042734],
cell projection [GO:0042995],
neuronal cell body [GO:0043025],
glutamatergic synapse [GO:0098978],
GABA-ergic synapse [GO:0098982],
integral component of presynaptic active zone membrane [GO:0099059],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
cell junction [GO:0030054],
endocytic vesicle [GO:0030139],
slit diaphragm [GO:0036057],
axonal growth cone [GO:0044295],
synapse [GO:0045202],
inhibitory synapse [GO:0060077],
integral component of presynaptic membrane [GO:0099056],