NRP1

neuropilin 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
angiogenesis [GO:0001525],
patterning of blood vessels [GO:0001569],
neuron migration [GO:0001764],
positive regulation of endothelial cell proliferation [GO:0001938],
sprouting angiogenesis [GO:0002040],
cell migration involved in sprouting angiogenesis [GO:0002042],
outflow tract septum morphogenesis [GO:0003148],
substrate-dependent cell migration, cell extension [GO:0006930],
signal transduction [GO:0007165],
integrin-mediated signaling pathway [GO:0007229],
cell-cell signaling [GO:0007267],
axon guidance [GO:0007411],
axonal fasciculation [GO:0007413],
response to wounding [GO:0009611],
animal organ morphogenesis [GO:0009887],
positive regulation of endothelial cell migration [GO:0010595],
positive regulation of smooth muscle cell migration [GO:0014911],
facial nerve structural organization [GO:0021612],
trigeminal nerve structural organization [GO:0021637],
vestibulocochlear nerve structural organization [GO:0021649],
nerve development [GO:0021675],
branchiomotor neuron axon guidance [GO:0021785],
gonadotrophin-releasing hormone neuronal migration to the hypothalamus [GO:0021828],
retinal ganglion cell axon guidance [GO:0031290],
actin cytoskeleton reorganization [GO:0031532],
regulation of Cdc42 protein signal transduction [GO:0032489],
substrate adhesion-dependent cell spreading [GO:0034446],
cellular response to hepatocyte growth factor stimulus [GO:0035729],
endothelial cell chemotaxis [GO:0035767],
cellular response to vascular endothelial growth factor stimulus [GO:0035924],
ventral trunk neural crest cell migration [GO:0036486],
neuropilin signaling pathway [GO:0038189],
VEGF-activated neuropilin signaling pathway [GO:0038190],
positive regulation of phosphorylation [GO:0042327],
negative regulation of neuron apoptotic process [GO:0043524],
endothelial cell migration [GO:0043542],
positive regulation of GTPase activity [GO:0043547],
platelet-derived growth factor receptor signaling pathway [GO:0048008],
vascular endothelial growth factor receptor signaling pathway [GO:0048010],
hepatocyte growth factor receptor signaling pathway [GO:0048012],
positive regulation of axon extension involved in axon guidance [GO:0048842],
negative regulation of axon extension involved in axon guidance [GO:0048843],
artery morphogenesis [GO:0048844],
axon extension involved in axon guidance [GO:0048846],
positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731],
positive chemotaxis [GO:0050918],
positive regulation of filopodium assembly [GO:0051491],
positive regulation of stress fiber assembly [GO:0051496],
positive regulation of focal adhesion assembly [GO:0051894],
positive regulation of cytokine activity [GO:0060301],
axonogenesis involved in innervation [GO:0060385],
regulation of vesicle-mediated transport [GO:0060627],
dichotomous subdivision of terminal units involved in salivary gland branching [GO:0060666],
angiogenesis involved in coronary vascular morphogenesis [GO:0060978],
coronary artery morphogenesis [GO:0060982],
retina vasculature morphogenesis in camera-type eye [GO:0061299],
renal artery morphogenesis [GO:0061441],
sympathetic ganglion development [GO:0061549],
trigeminal ganglion development [GO:0061551],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
semaphorin-plexin signaling pathway [GO:0071526],
commissural neuron axon guidance [GO:0071679],
positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050],
regulation of retinal ganglion cell axon guidance [GO:0090259],
endothelial tip cell fate specification [GO:0097102],
sensory neuron axon guidance [GO:0097374],
motor neuron migration [GO:0097475],
sympathetic neuron projection extension [GO:0097490],
sympathetic neuron projection guidance [GO:0097491],
positive regulation of substrate adhesion-dependent cell spreading [GO:1900026],
neural crest cell migration involved in autonomic nervous system development [GO:1901166],
toxin transport [GO:1901998],
semaphorin-plexin signaling pathway involved in neuron projection guidance [GO:1902285],
semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287],
positive regulation of retinal ganglion cell axon guidance [GO:1902336],
VEGF-activated neuropilin signaling pathway involved in axon guidance [GO:1902378],
protein localization to early endosome [GO:1902946],
facioacoustic ganglion development [GO:1903375],
dorsal root ganglion morphogenesis [GO:1904835],
otic placode development [GO:1905040],
positive regulation of actin cytoskeleton reorganization [GO:2000251],
negative regulation of extrinsic apoptotic signaling pathway [GO:2001237],
cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:0003253],
multicellular organism development [GO:0007275],
nervous system development [GO:0007399],
heart development [GO:0007507],
motor neuron axon guidance [GO:0008045],
dendrite development [GO:0016358],
cell migration [GO:0016477],
trigeminal nerve morphogenesis [GO:0021636],
cell differentiation [GO:0030154],
negative regulation of axon extension [GO:0030517],
vascular endothelial growth factor signaling pathway [GO:0038084],
positive regulation of angiogenesis [GO:0045766],
sympathetic nervous system development [GO:0048485],
neuron development [GO:0048666],
regulation of axon extension involved in axon guidance [GO:0048841],
cell migration involved in coronary vasculogenesis [GO:0060980],

Molecular Function:
vascular endothelial growth factor-activated receptor activity [GO:0005021],
GTPase activator activity [GO:0005096],
protein binding [GO:0005515],
heparin binding [GO:0008201],
coreceptor activity [GO:0015026],
semaphorin receptor activity [GO:0017154],
growth factor binding [GO:0019838],
protein kinase binding [GO:0019901],
cytokine binding [GO:0019955],
vascular endothelial growth factor binding [GO:0038085],
metal ion binding [GO:0046872],

Cellular Component:
semaphorin receptor complex [GO:0002116],
extracellular space [GO:0005615],
early endosome [GO:0005769],
cytosol [GO:0005829],
neurofilament [GO:0005883],
plasma membrane [GO:0005886],
focal adhesion [GO:0005925],
cell surface [GO:0009986],
axon [GO:0030424],
growth cone [GO:0030426],
cytoplasmic vesicle [GO:0031410],
mitochondrial membrane [GO:0031966],
neuron projection [GO:0043005],
neuronal cell body [GO:0043025],
receptor complex [GO:0043235],
sorting endosome [GO:0097443],
glutamatergic synapse [GO:0098978],
integral component of postsynaptic membrane [GO:0099055],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
membrane [GO:0016020],
integral component of membrane [GO:0016021],