NPEPPS

aminopeptidase puromycin sensitive

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES
29321003 Primary bronchial epithelial cells derived from lung Human YES
31945054 IMR-90 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31983656 MSC Human YES

GO terms:

Biological Process:
protein polyubiquitination [GO:0000209],
proteolysis [GO:0006508],
peptide catabolic process [GO:0043171],
cellular response to hypoxia [GO:0071456],
positive regulation of protein targeting to mitochondrion [GO:1903955],

Molecular Function:
aminopeptidase activity [GO:0004177],
zinc ion binding [GO:0008270],
peptide binding [GO:0042277],
metalloaminopeptidase activity [GO:0070006],
peptidase activity [GO:0008233],
metallopeptidase activity [GO:0008237],
hydrolase activity [GO:0016787],
metal ion binding [GO:0046872],

Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
extracellular exosome [GO:0070062],