NPC intracellular cholesterol transporter 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
32029712 Primary synovial fibroblast Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
protein glycosylation [GO:0006486],
endocytosis [GO:0006897],
autophagy [GO:0006914],
lysosomal transport [GO:0007041],
adult walking behavior [GO:0007628],
cholesterol metabolic process [GO:0008203],
bile acid metabolic process [GO:0008206],
negative regulation of macroautophagy [GO:0016242],
cholesterol transport [GO:0030301],
membrane raft organization [GO:0031579],
intracellular cholesterol transport [GO:0032367],
cholesterol efflux [GO:0033344],
low-density lipoprotein particle clearance [GO:0034383],
response to drug [GO:0042493],
cholesterol homeostasis [GO:0042632],
response to cadmium ion [GO:0046686],
viral entry into host cell [GO:0046718],
negative regulation of cell death [GO:0060548],
cellular response to steroid hormone stimulus [GO:0071383],
cellular response to low-density lipoprotein particle stimulus [GO:0071404],
establishment of protein localization to membrane [GO:0090150],
lipid metabolic process [GO:0006629],
lipid transport [GO:0006869],
steroid metabolic process [GO:0008202],

Molecular Function:
virus receptor activity [GO:0001618],
transmembrane signaling receptor activity [GO:0004888],
protein binding [GO:0005515],
sterol transporter activity [GO:0015248],
cholesterol binding [GO:0015485],
signaling receptor activity [GO:0038023],
lipid transporter activity [GO:0005319],

Cellular Component:
extracellular region [GO:0005576],
nuclear envelope [GO:0005635],
lysosome [GO:0005764],
lysosomal membrane [GO:0005765],
endoplasmic reticulum [GO:0005783],
Golgi apparatus [GO:0005794],
integral component of plasma membrane [GO:0005887],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
late endosome membrane [GO:0031902],
membrane raft [GO:0045121],
perinuclear region of cytoplasm [GO:0048471],
extracellular exosome [GO:0070062],
integral component of lysosomal membrane [GO:1905103],
endosome [GO:0005768],
plasma membrane [GO:0005886],
vesicle [GO:0031982],