NOX4

NADPH oxidase 4

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
19681754 HUVEC Human NO
21841825 Nthy-ori 3-1 Human NO
22659429 Primary cells derived from aorta Human NO
23216904 REF52, TIG-3, MEF Human, mouse, rat NO
23385065 BJ Human NO
24583638 BJ, HDF Human, mouse NO
24718857 Lung Human NO
24831009 IMR-90 Human NO
25982278 HeLa Human NO
27932314 Huh7 Human NO
28691365 EJ-1, NCI-H1299 Human NO
29147462 Primary cells derived from nucleus pulposus of intervertebral disc Rat NO
30912009 Adipose tissue Human NO
30977188 MSC Human YES
31464599 Primary fibroblasts derived from lung Human NO
31551807 H9c2(2-1) Rat NO
31631444 A549 Human NO
31945054 IMR-90 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
19409979 HUVEC Human NO
27655718 Primary cells derived from smooth muscle vascular Human NO

GO terms:

Biological Process:
cell morphogenesis [GO:0000902],
heart process [GO:0003015],
superoxide metabolic process [GO:0006801],
defense response [GO:0006952],
cell aging [GO:0007569],
negative regulation of cell proliferation [GO:0008285],
gene expression [GO:0010467],
positive regulation of smooth muscle cell migration [GO:0014911],
superoxide anion generation [GO:0042554],
positive regulation of apoptotic process [GO:0043065],
positive regulation of MAP kinase activity [GO:0043406],
bone resorption [GO:0045453],
homocysteine metabolic process [GO:0050667],
positive regulation of stress fiber assembly [GO:0051496],
positive regulation of protein kinase B signaling [GO:0051897],
cardiac muscle cell differentiation [GO:0055007],
oxidation-reduction process [GO:0055114],
positive regulation of protein tyrosine kinase activity [GO:0061098],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
cellular response to glucose stimulus [GO:0071333],
reactive oxygen species metabolic process [GO:0072593],
positive regulation of reactive oxygen species metabolic process [GO:2000379],
positive regulation of DNA biosynthetic process [GO:2000573],
response to hypoxia [GO:0001666],
inflammatory response [GO:0006954],
electron transport chain [GO:0022900],
cellular response to oxidative stress [GO:0034599],
cellular response to cAMP [GO:0071320],
cellular response to gamma radiation [GO:0071480],
cellular response to transforming growth factor beta stimulus [GO:0071560],
reactive oxygen species biosynthetic process [GO:1903409],

Molecular Function:
NAD(P)H oxidase activity [GO:0016174],
superoxide-generating NADPH oxidase activity [GO:0016175],
oxidoreductase activity [GO:0016491],
oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor [GO:0050664],
modified amino acid binding [GO:0072341],
protein tyrosine kinase binding [GO:1990782],
nucleotide binding [GO:0000166],
protein binding [GO:0005515],
electron carrier activity [GO:0009055],
oxygen sensor activity [GO:0019826],
heme binding [GO:0020037],
flavin adenine dinucleotide binding [GO:0050660],

Cellular Component:
stress fiber [GO:0001725],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
mitochondrion [GO:0005739],
endoplasmic reticulum [GO:0005783],
plasma membrane [GO:0005886],
focal adhesion [GO:0005925],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
apical plasma membrane [GO:0016324],
cell junction [GO:0030054],
NADPH oxidase complex [GO:0043020],
perinuclear region of cytoplasm [GO:0048471],
cell periphery [GO:0071944],
perinuclear endoplasmic reticulum [GO:0097038],
nucleolus [GO:0005730],
endoplasmic reticulum membrane [GO:0005789],