NOTCH1

notch receptor 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
20416178 Primary stromal cells derived from bone marrow Mouse NO
20578140 Chang, HUH7, HEPG2, Hep3B Liver Human, mouse NO
24931169 EPC1, EPC2, EN6, TE11 Human, mouse NO
25678553 Primary progenitor cells derived from muscle Muscle Mouse NO
27323328 Saos-2,H1299, HT18, MCF7, MDA-MB-231, Li-Fraumeni Human YES
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Saos-2 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
24950189 HUVEC Aorta Human, mouse NO
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
in utero embryonic development [GO:0001701],
cell fate specification [GO:0001708],
epithelial to mesenchymal transition [GO:0001837],
liver development [GO:0001889],
heart looping [GO:0001947],
sprouting angiogenesis [GO:0002040],
positive regulation of neuroblast proliferation [GO:0002052],
inflammatory response to antigenic stimulus [GO:0002437],
outflow tract morphogenesis [GO:0003151],
endocardium development [GO:0003157],
endocardium morphogenesis [GO:0003160],
atrioventricular node development [GO:0003162],
coronary vein morphogenesis [GO:0003169],
aortic valve morphogenesis [GO:0003180],
atrioventricular valve morphogenesis [GO:0003181],
coronary sinus valve morphogenesis [GO:0003182],
pulmonary valve morphogenesis [GO:0003184],
mitral valve formation [GO:0003192],
epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198],
endocardial cushion morphogenesis [GO:0003203],
cardiac chamber formation [GO:0003207],
cardiac ventricle morphogenesis [GO:0003208],
cardiac atrium morphogenesis [GO:0003209],
cardiac right atrium morphogenesis [GO:0003213],
cardiac left ventricle morphogenesis [GO:0003214],
cardiac right ventricle formation [GO:0003219],
ventricular trabecula myocardium morphogenesis [GO:0003222],
growth involved in heart morphogenesis [GO:0003241],
negative regulation of cell proliferation involved in heart valve morphogenesis [GO:0003252],
regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation [GO:0003256],
Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation [GO:0003270],
cell migration involved in endocardial cushion formation [GO:0003273],
negative regulation of extracellular matrix constituent secretion [GO:0003332],
pericardium morphogenesis [GO:0003344],
regulation of transcription, DNA-templated [GO:0006355],
transcription initiation from RNA polymerase II promoter [GO:0006367],
immune response [GO:0006955],
humoral immune response [GO:0006959],
cell cycle arrest [GO:0007050],
Notch signaling pathway [GO:0007219],
positive regulation of transcription of Notch receptor target [GO:0007221],
spermatogenesis [GO:0007283],
determination of left/right symmetry [GO:0007368],
compartment pattern specification [GO:0007386],
axonogenesis [GO:0007409],
axon guidance [GO:0007411],
foregut morphogenesis [GO:0007440],
endoderm development [GO:0007492],
heart development [GO:0007507],
positive regulation of cell proliferation [GO:0008284],
negative regulation of cell proliferation [GO:0008285],
auditory receptor cell fate commitment [GO:0009912],
negative regulation of cardiac muscle hypertrophy [GO:0010614],
positive regulation of gene expression [GO:0010628],
negative regulation of gene expression [GO:0010629],
negative regulation of cell-substrate adhesion [GO:0010812],
negative regulation of myotube differentiation [GO:0010832],
mesenchymal cell development [GO:0014031],
regulation of somitogenesis [GO:0014807],
cell differentiation in spinal cord [GO:0021515],
neural tube development [GO:0021915],
keratinocyte differentiation [GO:0030216],
negative regulation of ossification [GO:0030279],
lung development [GO:0030324],
positive regulation of cell migration [GO:0030335],
positive regulation of BMP signaling pathway [GO:0030513],
negative regulation of BMP signaling pathway [GO:0030514],
forebrain development [GO:0030900],
hair follicle morphogenesis [GO:0031069],
animal organ regeneration [GO:0031100],
response to corticosteroid [GO:0031960],
response to muramyl dipeptide [GO:0032495],
response to lipopolysaccharide [GO:0032496],
embryonic hindlimb morphogenesis [GO:0035116],
tube formation [GO:0035148],
skeletal muscle cell differentiation [GO:0035914],
cellular response to vascular endothelial growth factor stimulus [GO:0035924],
tissue regeneration [GO:0042246],
negative regulation of catalytic activity [GO:0043086],
positive regulation of viral genome replication [GO:0045070],
positive regulation of endothelial cell differentiation [GO:0045603],
negative regulation of auditory receptor cell differentiation [GO:0045608],
positive regulation of keratinocyte differentiation [GO:0045618],
negative regulation of myoblast differentiation [GO:0045662],
negative regulation of osteoblast differentiation [GO:0045668],
positive regulation of Notch signaling pathway [GO:0045747],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
negative regulation of calcium ion-dependent exocytosis [GO:0045955],
negative regulation of growth rate [GO:0045967],
positive regulation of JAK-STAT cascade [GO:0046427],
negative regulation of photoreceptor cell differentiation [GO:0046533],
positive regulation of Ras protein signal transduction [GO:0046579],
somatic stem cell division [GO:0048103],
astrocyte differentiation [GO:0048708],
oligodendrocyte differentiation [GO:0048709],
positive regulation of astrocyte differentiation [GO:0048711],
negative regulation of oligodendrocyte differentiation [GO:0048715],
branching morphogenesis of an epithelial tube [GO:0048754],
homeostasis of number of cells within a tissue [GO:0048873],
positive regulation of epithelial cell proliferation [GO:0050679],
negative regulation of neurogenesis [GO:0050768],
cardiac muscle tissue morphogenesis [GO:0055008],
cardiac muscle cell proliferation [GO:0060038],
positive regulation of cardiac muscle cell proliferation [GO:0060045],
negative regulation of glial cell proliferation [GO:0060253],
cilium assembly [GO:0060271],
cardiac epithelial to mesenchymal transition [GO:0060317],
negative regulation of cell adhesion molecule production [GO:0060354],
cardiac septum morphogenesis [GO:0060411],
ventricular septum morphogenesis [GO:0060412],
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development [GO:0060528],
prostate gland epithelium morphogenesis [GO:0060740],
regulation of epithelial cell proliferation involved in prostate gland development [GO:0060768],
arterial endothelial cell differentiation [GO:0060842],
venous endothelial cell differentiation [GO:0060843],
cardiac vascular smooth muscle cell development [GO:0060948],
endocardial cell differentiation [GO:0060956],
vasculogenesis involved in coronary vascular morphogenesis [GO:0060979],
coronary artery morphogenesis [GO:0060982],
Notch signaling involved in heart development [GO:0061314],
heart trabecula morphogenesis [GO:0061384],
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061419],
negative regulation of biomineral tissue development [GO:0070168],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
left/right axis specification [GO:0070986],
cellular response to follicle-stimulating hormone stimulus [GO:0071372],
distal tubule development [GO:0072017],
collecting duct development [GO:0072044],
glomerular mesangial cell development [GO:0072144],
interleukin-4 secretion [GO:0072602],
negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051],
negative regulation of canonical Wnt signaling pathway [GO:0090090],
neuronal stem cell population maintenance [GO:0097150],
regulation of extracellular matrix assembly [GO:1901201],
apoptotic process involved in embryonic digit morphogenesis [GO:1902263],
positive regulation of apoptotic process involved in morphogenesis [GO:1902339],
positive regulation of aorta morphogenesis [GO:1903849],
negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048],
negative regulation of stem cell differentiation [GO:2000737],
negative regulation of anoikis [GO:2000811],
negative regulation of pro-B cell differentiation [GO:2000974],
negative regulation of endothelial cell chemotaxis [GO:2001027],
angiogenesis [GO:0001525],
osteoblast fate commitment [GO:0002051],
endocardial cushion development [GO:0003197],
regulation of cardioblast proliferation [GO:0003264],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
multicellular organism development [GO:0007275],
epidermis development [GO:0008544],
regulation of Notch signaling pathway [GO:0008593],
glial cell differentiation [GO:0010001],
regulation of gene expression [GO:0010468],
positive regulation of epithelial to mesenchymal transition [GO:0010718],
cell differentiation [GO:0030154],
neuron differentiation [GO:0030182],
embryonic limb morphogenesis [GO:0030326],
regulation of cell migration [GO:0030334],
regulation of cell proliferation [GO:0042127],
anagen [GO:0042640],
positive regulation of apoptotic process [GO:0043065],
cell fate commitment [GO:0045165],
negative regulation of cell differentiation [GO:0045596],
regulation of auditory receptor cell differentiation [GO:0045607],
negative regulation of neuron differentiation [GO:0045665],
positive regulation of glial cell differentiation [GO:0045687],
neuron fate commitment [GO:0048663],
venous blood vessel morphogenesis [GO:0048845],
positive regulation of viral transcription [GO:0050434],
regulation of epithelial cell proliferation [GO:0050678],
regulation of neurogenesis [GO:0050767],
regulation of developmental process [GO:0050793],
negative regulation of cell death [GO:0060548],
regulation of cell adhesion involved in heart morphogenesis [GO:0061344],
positive regulation of ephrin receptor signaling pathway [GO:1901189],

Molecular Function:
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001228],
enzyme inhibitor activity [GO:0004857],
transmembrane signaling receptor activity [GO:0004888],
Notch binding [GO:0005112],
calcium ion binding [GO:0005509],
protein binding [GO:0005515],
enzyme binding [GO:0019899],
chromatin DNA binding [GO:0031490],
chromatin binding [GO:0003682],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
signaling receptor activity [GO:0038023],
sequence-specific DNA binding [GO:0043565],
metal ion binding [GO:0046872],

Cellular Component:
Golgi membrane [GO:0000139],
acrosomal vesicle [GO:0001669],
MAML1-RBP-Jkappa- ICN1 complex [GO:0002193],
extracellular region [GO:0005576],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
endoplasmic reticulum membrane [GO:0005789],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
adherens junction [GO:0005912],
cell surface [GO:0009986],
integral component of membrane [GO:0016021],
apical plasma membrane [GO:0016324],
receptor complex [GO:0043235],
cytoplasm [GO:0005737],
endoplasmic reticulum [GO:0005783],
Golgi apparatus [GO:0005794],
integral component of plasma membrane [GO:0005887],
membrane [GO:0016020],
cytoplasmic vesicle [GO:0031410],
cell periphery [GO:0071944],