NOS3

nitric oxide synthase 3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
21169404 Primary mononuclear cells derived from bone marrow Mouse NO
21678067 C85 Intestine Human NO
21980126 HUVEC, EPC, Primary pro-angiogenic cell Human NO
28153047 HUVEC, THP-1 Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
17071725 PAEC Bovinae NO
20705918 HUVEC Mouse NO
22238626 HUVEC Hippocampus Mouse NO
23336586 HUVEC Human NO
28544111 EPC, HEK 293T Human, mouse NO
29251114 EPC Liver Human, mouse NO
30048241 HUVEC Human NO
31158660 Primary endothelial cells derived from artery Pig NO
31581517 Primary cells derived form heart Pig NO
31750822 HUVEC Human NO
31878008 Heart Human NO

GO terms:

Biological Process:
angiogenesis [GO:0001525],
ovulation from ovarian follicle [GO:0001542],
in utero embryonic development [GO:0001701],
blood vessel remodeling [GO:0001974],
regulation of sodium ion transport [GO:0002028],
regulation of the force of heart contraction by chemical signal [GO:0003057],
regulation of systemic arterial blood pressure by endothelin [GO:0003100],
aortic valve morphogenesis [GO:0003180],
pulmonary valve morphogenesis [GO:0003184],
endocardial cushion morphogenesis [GO:0003203],
arginine catabolic process [GO:0006527],
nitric oxide biosynthetic process [GO:0006809],
mitochondrion organization [GO:0007005],
nitric oxide mediated signal transduction [GO:0007263],
regulation of blood pressure [GO:0008217],
negative regulation of cell proliferation [GO:0008285],
response to heat [GO:0009408],
response to hormone [GO:0009725],
negative regulation of platelet activation [GO:0010544],
positive regulation of gene expression [GO:0010628],
negative regulation of muscle hyperplasia [GO:0014740],
smooth muscle hyperplasia [GO:0014806],
removal of superoxide radicals [GO:0019430],
lung development [GO:0030324],
positive regulation of guanylate cyclase activity [GO:0031284],
regulation of neurological system process [GO:0031644],
lipopolysaccharide-mediated signaling pathway [GO:0031663],
response to lipopolysaccharide [GO:0032496],
response to fluid shear stress [GO:0034405],
vasodilation [GO:0042311],
negative regulation of potassium ion transport [GO:0043267],
positive regulation of blood vessel endothelial cell migration [GO:0043536],
endothelial cell migration [GO:0043542],
cell redox homeostasis [GO:0045454],
positive regulation of Notch signaling pathway [GO:0045747],
positive regulation of angiogenesis [GO:0045766],
negative regulation of blood pressure [GO:0045776],
negative regulation of smooth muscle cell proliferation [GO:0048662],
homeostasis of number of cells within a tissue [GO:0048873],
regulation of nitric-oxide synthase activity [GO:0050999],
negative regulation of hydrolase activity [GO:0051346],
negative regulation of calcium ion transport [GO:0051926],
oxidation-reduction process [GO:0055114],
ventricular septum morphogenesis [GO:0060412],
negative regulation of biomineral tissue development [GO:0070168],
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042],
signal transduction [GO:0007165],
response to estradiol [GO:0032355],
positive regulation of apoptotic process [GO:0043065],
cellular response to mechanical stimulus [GO:0071260],
cellular response to transforming growth factor beta stimulus [GO:0071560],

Molecular Function:
actin monomer binding [GO:0003785],
NADPH-hemoprotein reductase activity [GO:0003958],
nitric-oxide synthase activity [GO:0004517],
protein binding [GO:0005515],
calmodulin binding [GO:0005516],
FMN binding [GO:0010181],
oxidoreductase activity [GO:0016491],
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709],
heme binding [GO:0020037],
tetrahydrobiopterin binding [GO:0034617],
arginine binding [GO:0034618],
cadmium ion binding [GO:0046870],
flavin adenine dinucleotide binding [GO:0050660],
NADP binding [GO:0050661],
scaffold protein binding [GO:0097110],
actin binding [GO:0003779],
beta-catenin binding [GO:0008013],
cadherin binding [GO:0045296],
metal ion binding [GO:0046872],
nitric-oxide synthase binding [GO:0050998],
Hsp90 protein binding [GO:0051879],

Cellular Component:
Golgi membrane [GO:0000139],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
Golgi apparatus [GO:0005794],
cytosol [GO:0005829],
cytoskeleton [GO:0005856],
plasma membrane [GO:0005886],
caveola [GO:0005901],
vesicle membrane [GO:0012506],
endocytic vesicle membrane [GO:0030666],
nucleolus [GO:0005730],
mitochondrion [GO:0005739],
membrane [GO:0016020],
sarcolemma [GO:0042383],
membrane raft [GO:0045121],
apical part of cell [GO:0045177],