NOS3
nitric oxide synthase 3
Link to human orthologLink to mouse ortholog
Search for interactions with genes linked to senescence.
Status in senescence: Up-regulated | ||||
Pubmed ID | Cell line | Tissue | Source | High-throughput |
21169404 | Primary mononuclear cells derived from bone marrow | Mouse | NO | |
21678067 | C85 | Intestine | Human | NO |
21980126 | HUVEC, EPC, Primary pro-angiogenic cell | Human | NO | |
28153047 | HUVEC, THP-1 | Human | NO | |
Status in senescence: Down-regulated | ||||
Pubmed ID | Cell line | Tissue | Source | High-throughput |
17071725 | PAEC | Bovinae | NO | |
20705918 | HUVEC | Mouse | NO | |
22238626 | HUVEC | Hippocampus | Mouse | NO |
23336586 | HUVEC | Human | NO | |
28544111 | EPC, HEK 293T | Human, mouse | NO | |
29251114 | EPC | Liver | Human, mouse | NO |
30048241 | HUVEC | Human | NO | |
31158660 | Primary endothelial cells derived from artery | Pig | NO | |
31581517 | Primary cells derived form heart | Pig | NO | |
31750822 | HUVEC | Human | NO | |
31878008 | Heart | Human | NO |
GO terms:
Biological Process:
angiogenesis [GO:0001525],
ovulation from ovarian follicle [GO:0001542],
in utero embryonic development [GO:0001701],
blood vessel remodeling [GO:0001974],
regulation of sodium ion transport [GO:0002028],
regulation of the force of heart contraction by chemical signal [GO:0003057],
regulation of systemic arterial blood pressure by endothelin [GO:0003100],
aortic valve morphogenesis [GO:0003180],
pulmonary valve morphogenesis [GO:0003184],
endocardial cushion morphogenesis [GO:0003203],
arginine catabolic process [GO:0006527],
nitric oxide biosynthetic process [GO:0006809],
mitochondrion organization [GO:0007005],
nitric oxide mediated signal transduction [GO:0007263],
regulation of blood pressure [GO:0008217],
negative regulation of cell proliferation [GO:0008285],
response to heat [GO:0009408],
response to hormone [GO:0009725],
negative regulation of platelet activation [GO:0010544],
positive regulation of gene expression [GO:0010628],
negative regulation of muscle hyperplasia [GO:0014740],
smooth muscle hyperplasia [GO:0014806],
removal of superoxide radicals [GO:0019430],
lung development [GO:0030324],
positive regulation of guanylate cyclase activity [GO:0031284],
regulation of neurological system process [GO:0031644],
lipopolysaccharide-mediated signaling pathway [GO:0031663],
response to lipopolysaccharide [GO:0032496],
response to fluid shear stress [GO:0034405],
vasodilation [GO:0042311],
negative regulation of potassium ion transport [GO:0043267],
positive regulation of blood vessel endothelial cell migration [GO:0043536],
endothelial cell migration [GO:0043542],
cell redox homeostasis [GO:0045454],
positive regulation of Notch signaling pathway [GO:0045747],
positive regulation of angiogenesis [GO:0045766],
negative regulation of blood pressure [GO:0045776],
negative regulation of smooth muscle cell proliferation [GO:0048662],
homeostasis of number of cells within a tissue [GO:0048873],
regulation of nitric-oxide synthase activity [GO:0050999],
negative regulation of hydrolase activity [GO:0051346],
negative regulation of calcium ion transport [GO:0051926],
oxidation-reduction process [GO:0055114],
ventricular septum morphogenesis [GO:0060412],
negative regulation of biomineral tissue development [GO:0070168],
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042],
signal transduction [GO:0007165],
response to estradiol [GO:0032355],
positive regulation of apoptotic process [GO:0043065],
cellular response to mechanical stimulus [GO:0071260],
cellular response to transforming growth factor beta stimulus [GO:0071560],
Molecular Function:
actin monomer binding [GO:0003785],
NADPH-hemoprotein reductase activity [GO:0003958],
nitric-oxide synthase activity [GO:0004517],
protein binding [GO:0005515],
calmodulin binding [GO:0005516],
FMN binding [GO:0010181],
oxidoreductase activity [GO:0016491],
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709],
heme binding [GO:0020037],
tetrahydrobiopterin binding [GO:0034617],
arginine binding [GO:0034618],
cadmium ion binding [GO:0046870],
flavin adenine dinucleotide binding [GO:0050660],
NADP binding [GO:0050661],
scaffold protein binding [GO:0097110],
actin binding [GO:0003779],
beta-catenin binding [GO:0008013],
cadherin binding [GO:0045296],
metal ion binding [GO:0046872],
nitric-oxide synthase binding [GO:0050998],
Hsp90 protein binding [GO:0051879],
Cellular Component:
Golgi membrane [GO:0000139],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
Golgi apparatus [GO:0005794],
cytosol [GO:0005829],
cytoskeleton [GO:0005856],
plasma membrane [GO:0005886],
caveola [GO:0005901],
vesicle membrane [GO:0012506],
endocytic vesicle membrane [GO:0030666],
nucleolus [GO:0005730],
mitochondrion [GO:0005739],
membrane [GO:0016020],
sarcolemma [GO:0042383],
membrane raft [GO:0045121],
apical part of cell [GO:0045177],