NOS2

nitric oxide synthase 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
21678067 C85 Human NO
27845209 HeLa, A549, MRC5 Human NO
31491600 HAEC Human NO
31823179 Primary chondrocytes derived from cartillage Rat NO
31857155 Primary macrophages derived from peritoneum, EO771 Mouse NO
31972508 KGN Human NO
32062081 Kidney Mouse NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31972508 COV435 Human NO
32671444 MDA-MB-231 Human NO

GO terms:

Biological Process:
response to hypoxia [GO:0001666],
positive regulation of leukocyte mediated cytotoxicity [GO:0001912],
innate immune response in mucosa [GO:0002227],
arginine catabolic process [GO:0006527],
protein targeting to peroxisome [GO:0006625],
superoxide metabolic process [GO:0006801],
nitric oxide biosynthetic process [GO:0006809],
inflammatory response [GO:0006954],
nitric oxide mediated signal transduction [GO:0007263],
circadian rhythm [GO:0007623],
response to bacterium [GO:0009617],
response to hormone [GO:0009725],
negative regulation of gene expression [GO:0010629],
peptidyl-cysteine S-nitrosylation [GO:0018119],
cytokine-mediated signaling pathway [GO:0019221],
positive regulation of guanylate cyclase activity [GO:0031284],
prostaglandin secretion [GO:0032310],
response to lipopolysaccharide [GO:0032496],
cellular response to drug [GO:0035690],
regulation of cell proliferation [GO:0042127],
negative regulation of protein catabolic process [GO:0042177],
defense response to bacterium [GO:0042742],
regulation of cellular respiration [GO:0043457],
cell redox homeostasis [GO:0045454],
negative regulation of blood pressure [GO:0045776],
regulation of insulin secretion [GO:0050796],
defense response to Gram-negative bacterium [GO:0050829],
positive regulation of killing of cells of other organism [GO:0051712],
oxidation-reduction process [GO:0055114],
cellular response to lipopolysaccharide [GO:0071222],
cellular response to interferon-gamma [GO:0071346],
interleukin-6 secretion [GO:0072604],
interleukin-8 secretion [GO:0072606],
regulation of cytokine production involved in inflammatory response [GO:1900015],
ovulation from ovarian follicle [GO:0001542],
cellular response to cytokine stimulus [GO:0071345],
cellular response to organic cyclic compound [GO:0071407],

Molecular Function:
NADPH-hemoprotein reductase activity [GO:0003958],
nitric-oxide synthase activity [GO:0004517],
protein binding [GO:0005515],
calmodulin binding [GO:0005516],
FMN binding [GO:0010181],
oxidoreductase activity [GO:0016491],
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709],
heme binding [GO:0020037],
tetrahydrobiopterin binding [GO:0034617],
arginine binding [GO:0034618],
protein homodimerization activity [GO:0042803],
metal ion binding [GO:0046872],
flavin adenine dinucleotide binding [GO:0050660],
NADP binding [GO:0050661],
actin binding [GO:0003779],
beta-catenin binding [GO:0008013],
cAMP-dependent protein kinase regulator activity [GO:0008603],
protein kinase binding [GO:0019901],
identical protein binding [GO:0042802],
cadherin binding [GO:0045296],
nitric-oxide synthase binding [GO:0050998],
Hsp90 protein binding [GO:0051879],

Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],
peroxisome [GO:0005777],
peroxisomal matrix [GO:0005782],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
vesicle membrane [GO:0012506],
cortical cytoskeleton [GO:0030863],
perinuclear region of cytoplasm [GO:0048471],
extracellular space [GO:0005615],