ACACB

acetyl-CoA carboxylase beta

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
27323328 Saos-2,H1299, HT18, MCF7, MDA-MB-231, Li-Fraumeni Human YES
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Saos-2, Li-Fraumeni Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
30987592 MCF7 Breast Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
acetyl-CoA metabolic process [GO:0006084],
fatty acid biosynthetic process [GO:0006633],
carnitine shuttle [GO:0006853],
negative regulation of gene expression [GO:0010629],
positive regulation of lipid storage [GO:0010884],
regulation of glucose metabolic process [GO:0010906],
response to organic cyclic compound [GO:0014070],
positive regulation of cellular metabolic process [GO:0031325],
response to nutrient levels [GO:0031667],
negative regulation of fatty acid beta-oxidation [GO:0031999],
response to drug [GO:0042493],
negative regulation of catalytic activity [GO:0043086],
regulation of cholesterol biosynthetic process [GO:0045540],
protein homotetramerization [GO:0051289],
positive regulation of heart growth [GO:0060421],
energy homeostasis [GO:0097009],
malonyl-CoA biosynthetic process [GO:2001295],
lipid metabolic process [GO:0006629],
fatty acid metabolic process [GO:0006631],
metabolic process [GO:0008152],
negative regulation of fatty acid oxidation [GO:0046322],
negative regulation of lipid catabolic process [GO:0050995],

Molecular Function:
acetyl-CoA carboxylase activity [GO:0003989],
protein binding [GO:0005515],
ATP binding [GO:0005524],
biotin binding [GO:0009374],
identical protein binding [GO:0042802],
metal ion binding [GO:0046872],
nucleotide binding [GO:0000166],
catalytic activity [GO:0003824],
ligase activity [GO:0016874],

Cellular Component:
nucleus [GO:0005634],
mitochondrion [GO:0005739],
mitochondrial outer membrane [GO:0005741],
cytosol [GO:0005829],