ATF5

activating transcription factor 5

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Li Fraumeni Human YES
31945054 IMR-90 Human YES

GO terms:

Biological Process:
regulation of transcription, DNA-templated [GO:0006355],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
circadian rhythm [GO:0007623],
negative regulation of cell proliferation [GO:0008285],
post-embryonic development [GO:0009791],
olfactory bulb interneuron development [GO:0021891],
cerebellar granule cell precursor proliferation [GO:0021930],
multicellular organism growth [GO:0035264],
negative regulation of apoptotic process [GO:0043066],
fat cell differentiation [GO:0045444],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
regulation of centrosome cycle [GO:0046605],
negative regulation of cell cycle G2/M phase transition [GO:1902750],
regulation of gene expression [GO:0010468],
olfactory bulb interneuron differentiation [GO:0021889],
olfactory lobe development [GO:0021988],
regulation of cell proliferation [GO:0042127],
negative regulation of astrocyte differentiation [GO:0048712],
negative regulation of neurogenesis [GO:0050768],
regulation of cell cycle [GO:0051726],

Molecular Function:
transcription regulatory region sequence-specific DNA binding [GO:0000976],
RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001228],
chromatin binding [GO:0003682],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
transcription corepressor activity [GO:0003714],
protein binding [GO:0005515],
tubulin binding [GO:0015631],
kinase binding [GO:0019900],
sequence-specific DNA binding [GO:0043565],
DNA binding [GO:0003677],
heat shock protein binding [GO:0031072],

Cellular Component:
nuclear chromatin [GO:0000790],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
transcription factor complex [GO:0005667],
centrosome [GO:0005813],
cytosol [GO:0005829],
cytoplasm [GO:0005737],
cytoskeleton [GO:0005856],