NOD2

nucleotide binding oligomerization domain containing 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
33296652 heart heart Human NO

GO terms:

Biological Process:
activation of MAPK activity [GO:0000187],
pattern recognition receptor signaling pathway [GO:0002221],
cytokine production involved in immune response [GO:0002367],
cytokine secretion involved in immune response [GO:0002374],
positive regulation of dendritic cell antigen processing and presentation [GO:0002606],
positive regulation of dendritic cell cytokine production [GO:0002732],
positive regulation of type 2 immune response [GO:0002830],
defense response [GO:0006952],
JNK cascade [GO:0007254],
response to nutrient [GO:0007584],
detection of biotic stimulus [GO:0009595],
detection of bacterium [GO:0016045],
maintenance of gastrointestinal epithelium [GO:0030277],
response to muramyl dipeptide [GO:0032495],
detection of muramyl dipeptide [GO:0032498],
positive regulation of interleukin-1 beta production [GO:0032731],
positive regulation of interleukin-10 production [GO:0032733],
positive regulation of interleukin-17 production [GO:0032740],
positive regulation of interleukin-6 production [GO:0032755],
positive regulation of interleukin-8 production [GO:0032757],
positive regulation of tumor necrosis factor production [GO:0032760],
positive regulation of stress-activated MAPK cascade [GO:0032874],
intracellular signal transduction [GO:0035556],
defense response to bacterium [GO:0042742],
positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123],
positive regulation of MAP kinase activity [GO:0043406],
positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552],
innate immune response [GO:0045087],
positive regulation of Notch signaling pathway [GO:0045747],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of JNK cascade [GO:0046330],
positive regulation of gamma-delta T cell activation [GO:0046645],
positive regulation of epithelial cell proliferation [GO:0050679],
positive regulation of interleukin-1 beta secretion [GO:0050718],
regulation of inflammatory response [GO:0050727],
positive regulation of B cell activation [GO:0050871],
positive regulation of NF-kappaB transcription factor activity [GO:0051092],
positive regulation of oxidoreductase activity [GO:0051353],
positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770],
positive regulation of prostaglandin-endoperoxide synthase activity [GO:0060585],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
nucleotide-binding oligomerization domain containing signaling pathway [GO:0070423],
nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431],
interleukin-1-mediated signaling pathway [GO:0070498],
cellular response to lipopolysaccharide [GO:0071222],
cellular response to peptidoglycan [GO:0071224],
cellular response to muramyl dipeptide [GO:0071225],
cellular response to organic cyclic compound [GO:0071407],
positive regulation of cytokine production involved in inflammatory response [GO:1900017],
positive regulation of NIK/NF-kappaB signaling [GO:1901224],
positive regulation of protein K63-linked ubiquitination [GO:1902523],
negative regulation of macrophage apoptotic process [GO:2000110],
positive regulation of prostaglandin-E synthase activity [GO:2000363],
innate immune response in mucosa [GO:0002227],
activation of immune response [GO:0002253],
immune system process [GO:0002376],
immunoglobulin production involved in immunoglobulin mediated immune response [GO:0002381],
negative regulation of T cell mediated immunity [GO:0002710],
negative regulation of inflammatory response to antigenic stimulus [GO:0002862],
positive regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002925],
inflammatory response [GO:0006954],
positive regulation of antibacterial peptide biosynthetic process [GO:0006963],
positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria [GO:0006965],
signal transduction [GO:0007165],
positive regulation of cell proliferation [GO:0008284],
positive regulation of protein ubiquitination [GO:0031398],
negative regulation of NF-kappaB transcription factor activity [GO:0032088],
response to peptidoglycan [GO:0032494],
response to lipopolysaccharide [GO:0032496],
negative regulation of interferon-gamma production [GO:0032689],
negative regulation of interleukin-12 production [GO:0032695],
negative regulation of interleukin-18 production [GO:0032701],
negative regulation of interleukin-2 production [GO:0032703],
negative regulation of tumor necrosis factor production [GO:0032720],
positive regulation of interleukin-12 production [GO:0032735],
negative regulation of toll-like receptor 2 signaling pathway [GO:0034136],
regulation of apoptotic process [GO:0042981],
response to exogenous dsRNA [GO:0043330],
positive regulation of MAPK cascade [GO:0043410],
positive regulation of innate immune response [GO:0045089],
positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731],
positive regulation of phagocytosis [GO:0050766],
defense response to Gram-positive bacterium [GO:0050830],
macrophage inflammatory protein-1 alpha production [GO:0071608],
positive regulation of monocyte chemotactic protein-1 production [GO:0071639],
regulation of neutrophil chemotaxis [GO:0090022],
positive regulation of xenophagy [GO:1904417],

Molecular Function:
actin binding [GO:0003779],
protein binding [GO:0005515],
ATP binding [GO:0005524],
enzyme binding [GO:0019899],
protein kinase binding [GO:0019901],
Hsp70 protein binding [GO:0030544],
muramyl dipeptide binding [GO:0032500],
pattern recognition receptor activity [GO:0038187],
peptidoglycan binding [GO:0042834],
macromolecular complex binding [GO:0044877],
CARD domain binding [GO:0050700],
Hsp90 protein binding [GO:0051879],
nucleotide binding [GO:0000166],
endodeoxyribonuclease activity, producing 5'-phosphomonoesters [GO:0016888],

Cellular Component:
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
Golgi apparatus [GO:0005794],
cytosol [GO:0005829],
cytoskeleton [GO:0005856],
plasma membrane [GO:0005886],
cell surface [GO:0009986],
basolateral plasma membrane [GO:0016323],
vesicle [GO:0031982],
macromolecular complex [GO:0032991],
phagocytic vesicle [GO:0045335],
anchored component of plasma membrane [GO:0046658],
membrane [GO:0016020],