nucleotide binding oligomerization domain containing 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF, HCA779 Skin, Lung Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
activation of MAPK activity [GO:0000187],
pattern recognition receptor signaling pathway [GO:0002221],
positive regulation of dendritic cell antigen processing and presentation [GO:0002606],
apoptotic process [GO:0006915],
activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919],
defense response [GO:0006952],
inflammatory response [GO:0006954],
signal transduction [GO:0007165],
JNK cascade [GO:0007254],
detection of biotic stimulus [GO:0009595],
detection of bacterium [GO:0016045],
positive regulation of interleukin-1 beta production [GO:0032731],
positive regulation of interleukin-6 production [GO:0032755],
positive regulation of tumor necrosis factor production [GO:0032760],
intracellular signal transduction [GO:0035556],
interleukin-8 biosynthetic process [GO:0042228],
defense response to bacterium [GO:0042742],
positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123],
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280],
innate immune response [GO:0045087],
positive regulation of JNK cascade [GO:0046330],
defense response to Gram-positive bacterium [GO:0050830],
positive regulation of nitric-oxide synthase activity [GO:0051000],
positive regulation of NF-kappaB transcription factor activity [GO:0051092],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
nucleotide-binding oligomerization domain containing signaling pathway [GO:0070423],
interleukin-1-mediated signaling pathway [GO:0070498],
cellular response to muramyl dipeptide [GO:0071225],
positive regulation of NIK/NF-kappaB signaling [GO:1901224],
positive regulation of xenophagy [GO:1904417],
immune system process [GO:0002376],
positive regulation of cell death [GO:0010942],
positive regulation of stress-activated MAPK cascade [GO:0032874],
regulation of apoptotic process [GO:0042981],

Molecular Function:
protein binding [GO:0005515],
ATP binding [GO:0005524],
cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656],
pattern recognition receptor activity [GO:0038187],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
peptidoglycan binding [GO:0042834],
macromolecular complex binding [GO:0044877],
CARD domain binding [GO:0050700],
nucleotide binding [GO:0000166],

Cellular Component:
cytoplasm [GO:0005737],
cytosol [GO:0005829],
basolateral plasma membrane [GO:0016323],
apical plasma membrane [GO:0016324],
anchored component of plasma membrane [GO:0046658],
plasma membrane [GO:0005886],
membrane [GO:0016020],
phagocytic vesicle [GO:0045335],