ATF4

activating transcription factor 4

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
25567807 RTECs Kidney Human, mouse NO
28894140 HK-3 Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
gluconeogenesis [GO:0006094],
regulation of transcription, DNA-templated [GO:0006355],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
transcription from RNA polymerase II promoter [GO:0006366],
cellular calcium ion homeostasis [GO:0006874],
gamma-aminobutyric acid signaling pathway [GO:0007214],
response to toxic substance [GO:0009636],
positive regulation of vascular endothelial growth factor production [GO:0010575],
positive regulation of gene expression [GO:0010628],
neuron differentiation [GO:0030182],
negative regulation of translational initiation in response to stress [GO:0032057],
circadian regulation of gene expression [GO:0032922],
cellular response to amino acid starvation [GO:0034198],
cellular response to UV [GO:0034644],
response to endoplasmic reticulum stress [GO:0034976],
positive regulation of transcription from RNA polymerase II promoter in response to stress [GO:0036003],
positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress [GO:0036091],
PERK-mediated unfolded protein response [GO:0036499],
cellular response to glucose starvation [GO:0042149],
mRNA transcription from RNA polymerase II promoter [GO:0042789],
positive regulation of apoptotic process [GO:0043065],
negative regulation of potassium ion transport [GO:0043267],
positive regulation of neuron apoptotic process [GO:0043525],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase I promoter [GO:0045943],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance [GO:0061395],
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059],
positive regulation of biomineral tissue development [GO:0070169],
cellular response to oxygen-glucose deprivation [GO:0090650],
negative regulation of oxidative stress-induced neuron death [GO:1903204],
cellular response to dopamine [GO:1903351],
positive regulation of vascular associated smooth muscle cell apoptotic process [GO:1905461],
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990440],
response to manganese-induced endoplasmic reticulum stress [GO:1990737],
positive regulation of sodium-dependent phosphate transport [GO:2000120],
circadian rhythm [GO:0007623],
rhythmic process [GO:0048511],

Molecular Function:
transcription regulatory region sequence-specific DNA binding [GO:0000976],
RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977],
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
RNA polymerase II transcription factor binding [GO:0001085],
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001228],
DNA binding [GO:0003677],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
protein binding [GO:0005515],
protein C-terminus binding [GO:0008022],
protein kinase binding [GO:0019901],
leucine zipper domain binding [GO:0043522],
sequence-specific DNA binding [GO:0043565],
transcription factor binding [GO:0008134],

Cellular Component:
nuclear chromatin [GO:0000790],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
centrosome [GO:0005813],
dendrite membrane [GO:0032590],
macromolecular complex [GO:0032991],
nuclear periphery [GO:0034399],
neuron projection [GO:0043005],
Lewy body core [GO:1990037],
ATF4-CREB1 transcription factor complex [GO:1990589],
ATF1-ATF4 transcription factor complex [GO:1990590],
CHOP-ATF4 complex [GO:1990617],
transcription factor complex [GO:0005667],
cytoskeleton [GO:0005856],
plasma membrane [GO:0005886],
membrane [GO:0016020],
RNA polymerase II transcription factor complex [GO:0090575],