ATF3
activating transcription factor 3
Link to human orthologLink to mouse ortholog
Search for interactions with genes linked to senescence.
Status in senescence: Up-regulated | ||||
| Pubmed ID | Cell line | Tissue | Source | High-throughput |
| 29081404 | IMR-90 | Human | NO | |
| 29548335 | Saos-2, Li-Fraumeni | Human | YES | |
| 31945125 | Primary astrocytes derived from brain | Human | YES | |
Status in senescence: Down-regulated | ||||
| Pubmed ID | Cell line | Tissue | Source | High-throughput |
| 20485437 | HKCs | Skin | Human, mouse | NO |
| 29321003 | Primary bronchial epithelial cells derived from lung | Human | YES | |
GO terms:
Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
gluconeogenesis [GO:0006094],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
positive regulation of cell proliferation [GO:0008284],
cellular response to amino acid starvation [GO:0034198],
skeletal muscle cell differentiation [GO:0035914],
PERK-mediated unfolded protein response [GO:0036499],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance [GO:0061394],
negative regulation of ERK1 and ERK2 cascade [GO:0070373],
positive regulation of TRAIL-activated apoptotic signaling pathway [GO:1903984],
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990440],
regulation of transcription, DNA-templated [GO:0006355],
positive regulation of gene expression [GO:0010628],
endoplasmic reticulum unfolded protein response [GO:0030968],
negative regulation of transcription, DNA-templated [GO:0045892],
Molecular Function:
transcription regulatory region sequence-specific DNA binding [GO:0000976],
RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977],
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001227],
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001228],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
transcription corepressor activity [GO:0003714],
protein binding [GO:0005515],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
protein heterodimerization activity [GO:0046982],
DNA binding [GO:0003677],
Cellular Component:
nuclear chromatin [GO:0000790],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
nucleolus [GO:0005730],
CHOP-ATF3 complex [GO:1990622],