NLGN1

neuroligin 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES
30988157 IMR-90 Human YES

GO terms:

Biological Process:
regulation of respiratory gaseous exchange by neurological system process [GO:0002087],
protein targeting [GO:0006605],
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157],
neuron cell-cell adhesion [GO:0007158],
chemical synaptic transmission [GO:0007268],
nervous system development [GO:0007399],
synapse assembly [GO:0007416],
positive regulation of circadian sleep/wake cycle, wakefulness [GO:0010841],
synaptic vesicle targeting [GO:0016080],
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339],
neuronal signal transduction [GO:0023041],
neuron projection development [GO:0031175],
positive regulation of synaptic transmission, GABAergic [GO:0032230],
protein localization to synapse [GO:0035418],
establishment of protein localization [GO:0045184],
regulation of neuron differentiation [GO:0045664],
synaptic vesicle endocytosis [GO:0048488],
synaptic vesicle transport [GO:0048489],
rhythmic process [GO:0048511],
cytoskeletal matrix organization at active zone [GO:0048789],
modulation of synaptic transmission [GO:0050804],
positive regulation of filopodium assembly [GO:0051491],
positive regulation of synapse assembly [GO:0051965],
positive regulation of synaptic transmission, glutamatergic [GO:0051968],
long-term synaptic potentiation [GO:0060291],
positive regulation of dendritic spine development [GO:0060999],
negative regulation of dendritic spine morphogenesis [GO:0061002],
cellular response to calcium ion [GO:0071277],
terminal button organization [GO:0072553],
synaptic vesicle clustering [GO:0097091],
postsynaptic membrane assembly [GO:0097104],
presynaptic membrane assembly [GO:0097105],
AMPA glutamate receptor clustering [GO:0097113],
NMDA glutamate receptor clustering [GO:0097114],
neurexin clustering involved in presynaptic membrane assembly [GO:0097115],
postsynaptic density protein 95 clustering [GO:0097119],
receptor localization to synapse [GO:0097120],
retrograde trans-synaptic signaling by trans-synaptic protein complex [GO:0098942],
presynapse assembly [GO:0099054],
synaptic membrane adhesion [GO:0099560],
positive regulation of ruffle assembly [GO:1900029],
positive regulation of synaptic vesicle endocytosis [GO:1900244],
positive regulation of protein localization to synapse [GO:1902474],
positive regulation of intracellular signal transduction [GO:1902533],
excitatory synapse assembly [GO:1904861],
positive regulation of presynaptic active zone assembly [GO:1905520],
positive regulation of synaptic vesicle exocytosis [GO:2000302],
regulation of N-methyl-D-aspartate selective glutamate receptor activity [GO:2000310],
regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [GO:2000311],
positive regulation of excitatory postsynaptic potential [GO:2000463],
positive regulation of synaptic vesicle clustering [GO:2000809],
cell adhesion [GO:0007155],
synapse organization [GO:0050808],
inhibitory postsynaptic potential [GO:0060080],

Molecular Function:
beta-amyloid binding [GO:0001540],
PDZ domain binding [GO:0030165],
signaling receptor activity [GO:0038023],
neurexin family protein binding [GO:0042043],
identical protein binding [GO:0042802],
macromolecular complex binding [GO:0044877],
cell adhesion molecule binding [GO:0050839],
scaffold protein binding [GO:0097110],
protein binding [GO:0005515],

Cellular Component:
Golgi apparatus [GO:0005794],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
external side of plasma membrane [GO:0009897],
cell surface [GO:0009986],
postsynaptic density [GO:0014069],
NMDA selective glutamate receptor complex [GO:0017146],
dendrite [GO:0030425],
filopodium tip [GO:0032433],
synaptic cleft [GO:0043083],
dendritic spine [GO:0043197],
dendritic shaft [GO:0043198],
receptor complex [GO:0043235],
synapse [GO:0045202],
excitatory synapse [GO:0060076],
spanning component of membrane [GO:0089717],
presynapse [GO:0098793],
postsynapse [GO:0098794],
asymmetric, glutamatergic, excitatory synapse [GO:0098985],
integral component of postsynaptic membrane [GO:0099055],
integral component of postsynaptic specialization membrane [GO:0099060],
extracellular region [GO:0005576],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
cell junction [GO:0030054],
glutamatergic synapse [GO:0098978],