NGFR

nerve growth factor receptor

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
27323328 Saos-2,H1299, HT18, MCF7, MDA-MB-231, Li-Fraumeni Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
cellular glucose homeostasis [GO:0001678],
intracellular protein transport [GO:0006886],
activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919],
Rho protein signal transduction [GO:0007266],
axon guidance [GO:0007411],
central nervous system development [GO:0007417],
detection of temperature stimulus [GO:0016048],
nerve development [GO:0021675],
hair follicle morphogenesis [GO:0031069],
membrane protein intracellular domain proteolysis [GO:0031293],
circadian regulation of gene expression [GO:0032922],
dorsal aorta development [GO:0035907],
negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037],
positive regulation of odontogenesis of dentin-containing tooth [GO:0042488],
glucose homeostasis [GO:0042593],
positive regulation of apoptotic process [GO:0043065],
negative regulation of apoptotic process [GO:0043066],
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154],
regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043281],
neurotrophin TRK receptor signaling pathway [GO:0048011],
positive regulation of fibroblast proliferation [GO:0048146],
negative regulation of axonogenesis [GO:0050771],
positive regulation of axonogenesis [GO:0050772],
neuron apoptotic process [GO:0051402],
negative regulation of hair follicle development [GO:0051799],
positive regulation of protein localization to nucleus [GO:1900182],
positive regulation of pri-miRNA transcription from RNA polymerase II promoter [GO:1902895],
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903588],
cellular response to beta-amyloid [GO:1904646],
positive regulation of apoptotic signaling pathway [GO:2001235],
apoptotic process [GO:0006915],
signal transduction [GO:0007165],
multicellular organism development [GO:0007275],
nervous system development [GO:0007399],
circadian rhythm [GO:0007623],
response to wounding [GO:0009611],
regulation of gene expression [GO:0010468],
regulation of cell death [GO:0010941],
positive regulation of neuron projection development [GO:0010976],
negative regulation of neuron projection development [GO:0010977],
negative regulation of angiogenesis [GO:0016525],
sensory perception of pain [GO:0019233],
cell differentiation [GO:0030154],
positive regulation of myelination [GO:0031643],
positive regulation of synaptic transmission, cholinergic [GO:0032224],
cellular response to oxidative stress [GO:0034599],
positive regulation of Rho protein signal transduction [GO:0035025],
positive regulation of MAPK cascade [GO:0043410],
negative regulation of neuron apoptotic process [GO:0043524],
skin development [GO:0043588],
positive regulation of neuron differentiation [GO:0045666],
rhythmic process [GO:0048511],
positive regulation of protein kinase B signaling [GO:0051897],
negative regulation of mitochondrial depolarization [GO:0051902],
positive regulation of synaptic transmission, glutamatergic [GO:0051968],
negative regulation of dendritic spine development [GO:0061000],
positive regulation of neuron death [GO:1901216],
positive regulation of neural precursor cell proliferation [GO:2000179],
regulation of reactive oxygen species metabolic process [GO:2000377],
positive regulation of excitatory postsynaptic potential [GO:2000463],

Molecular Function:
beta-amyloid binding [GO:0001540],
transmembrane signaling receptor activity [GO:0004888],
death receptor activity [GO:0005035],
protein binding [GO:0005515],
calmodulin binding [GO:0005516],
coreceptor activity [GO:0015026],
Rab GTPase binding [GO:0017137],
ubiquitin protein ligase binding [GO:0031625],
signaling receptor activity [GO:0038023],
neurotrophin binding [GO:0043121],
nerve growth factor binding [GO:0048406],
neurotrophin TRKA receptor binding [GO:0005168],
identical protein binding [GO:0042802],
macromolecular complex binding [GO:0044877],
preprotein binding [GO:0070678],

Cellular Component:
extracellular region [GO:0005576],
nucleoplasm [GO:0005654],
endosome [GO:0005768],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
cell-cell junction [GO:0005911],
cell surface [GO:0009986],
postsynaptic density [GO:0014069],
integral component of membrane [GO:0016021],
growth cone [GO:0030426],
dendritic spine [GO:0043197],
perikaryon [GO:0043204],
nucleus [GO:0005634],
nuclear envelope [GO:0005635],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
rough endoplasmic reticulum [GO:0005791],
Golgi apparatus [GO:0005794],
external side of plasma membrane [GO:0009897],
membrane [GO:0016020],
cell junction [GO:0030054],
coated vesicle [GO:0030135],
dendrite membrane [GO:0032590],
neuronal cell body membrane [GO:0032809],
cell projection [GO:0042995],
membrane raft [GO:0045121],
synapse [GO:0045202],
clathrin-coated endocytic vesicle [GO:0045334],