NFIB

nuclear factor I B

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
chondrocyte differentiation [GO:0002062],
DNA replication [GO:0006260],
brain development [GO:0007420],
response to bacterium [GO:0009617],
glial cell differentiation [GO:0010001],
principal sensory nucleus of trigeminal nerve development [GO:0021740],
anterior commissure morphogenesis [GO:0021960],
hindbrain development [GO:0030902],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
Clara cell differentiation [GO:0060486],
Type I pneumocyte differentiation [GO:0060509],
Type II pneumocyte differentiation [GO:0060510],
salivary gland cavitation [GO:0060662],
cell differentiation involved in salivary gland development [GO:0060689],
lung ciliated cell differentiation [GO:0061141],
commissural neuron axon guidance [GO:0071679],
negative regulation of pri-miRNA transcription from RNA polymerase II promoter [GO:1902894],
negative regulation of mesenchymal cell proliferation involved in lung development [GO:2000791],
negative regulation of epithelial cell proliferation involved in lung morphogenesis [GO:2000795],
regulation of transcription, DNA-templated [GO:0006355],
negative regulation of cell proliferation [GO:0008285],
lung development [GO:0030324],
forebrain development [GO:0030900],
negative regulation of DNA binding [GO:0043392],

Molecular Function:
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001228],
DNA binding [GO:0003677],
double-stranded DNA binding [GO:0003690],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
transcription corepressor activity [GO:0003714],

Cellular Component:
nuclear chromatin [GO:0000790],
fibrillar center [GO:0001650],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cerebellar mossy fiber [GO:0044300],
intracellular [GO:0005622],