ASXL1

ASXL transcriptional regulator 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
28701722 MEF Mouse NO
28844647 BJ, WI-38, IMR-90, MRC-5, HFF, HCA117 Skin, Lung Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
cell morphogenesis [GO:0000902],
heart morphogenesis [GO:0003007],
transcription, DNA-templated [GO:0006351],
animal organ morphogenesis [GO:0009887],
negative regulation of lipid storage [GO:0010888],
protein deubiquitination [GO:0016579],
hemopoiesis [GO:0030097],
response to retinoic acid [GO:0032526],
negative regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035359],
monoubiquitinated histone H2A deubiquitination [GO:0035522],
regulation of kidney size [GO:0035564],
negative regulation of fat cell differentiation [GO:0045599],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of retinoic acid receptor signaling pathway [GO:0048386],
thymus development [GO:0048538],
bone marrow development [GO:0048539],
homeostasis of number of cells [GO:0048872],
lung saccule development [GO:0060430],
glomerular visceral epithelial cell development [GO:0072015],
chromatin organization [GO:0006325],
regulation of transcription, DNA-templated [GO:0006355],
hematopoietic or lymphoid organ development [GO:0048534],
bone development [GO:0060348],

Molecular Function:
DNA binding [GO:0003677],
chromatin binding [GO:0003682],
transcription coactivator activity [GO:0003713],
protein binding [GO:0005515],
retinoic acid receptor binding [GO:0042974],
peroxisome proliferator activated receptor binding [GO:0042975],
metal ion binding [GO:0046872],

Cellular Component:
nuclear chromatin [GO:0000790],
nucleoplasm [GO:0005654],
PR-DUB complex [GO:0035517],
nucleus [GO:0005634],