NF2

neurofibromin 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
mesoderm formation [GO:0001707],
negative regulation of cell-matrix adhesion [GO:0001953],
negative regulation of protein kinase activity [GO:0006469],
ectoderm development [GO:0007398],
negative regulation of cell proliferation [GO:0008285],
Schwann cell proliferation [GO:0014010],
regulation of gliogenesis [GO:0014013],
hippocampus development [GO:0021766],
negative regulation of cell-cell adhesion [GO:0022408],
actin cytoskeleton organization [GO:0030036],
negative regulation of cell migration [GO:0030336],
regulation of protein stability [GO:0031647],
regulation of hippo signaling [GO:0035330],
odontogenesis of dentin-containing tooth [GO:0042475],
negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532],
regulation of apoptotic process [GO:0042981],
negative regulation of MAPK cascade [GO:0043409],
cell-cell junction organization [GO:0045216],
positive regulation of cell differentiation [GO:0045597],
negative regulation of JAK-STAT cascade [GO:0046426],
positive regulation of stress fiber assembly [GO:0051496],
regulation of cell cycle [GO:0051726],
lens fiber cell differentiation [GO:0070306],
regulation of stem cell proliferation [GO:0072091],
regulation of protein localization to nucleus [GO:1900180],
regulation of neural precursor cell proliferation [GO:2000177],
brain development [GO:0007420],
negative regulation of cell growth [GO:0030308],
regulation of cell proliferation [GO:0042127],
regulation of neurogenesis [GO:0050767],

Molecular Function:
actin binding [GO:0003779],
protein binding [GO:0005515],
integrin binding [GO:0005178],
beta-catenin binding [GO:0008013],
cytoskeletal protein binding [GO:0008092],
protein domain specific binding [GO:0019904],

Cellular Component:
nucleus [GO:0005634],
nucleolus [GO:0005730],
cytoplasm [GO:0005737],
early endosome [GO:0005769],
cytosol [GO:0005829],
cytoskeleton [GO:0005856],
plasma membrane [GO:0005886],
adherens junction [GO:0005912],
membrane [GO:0016020],
lamellipodium [GO:0030027],
cortical actin cytoskeleton [GO:0030864],
filopodium membrane [GO:0031527],
cleavage furrow [GO:0032154],
ruffle membrane [GO:0032587],
neuron projection [GO:0043005],
cell body [GO:0044297],
apical part of cell [GO:0045177],
perinuclear region of cytoplasm [GO:0048471],
ruffle [GO:0001726],
filopodium [GO:0030175],
macromolecular complex [GO:0032991],
cell projection [GO:0042995],
membrane raft [GO:0045121],
synapse [GO:0045202],