argininosuccinate synthase 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30988157 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
19409979 HUVEC Human NO
31983656 MSC Human YES

GO terms:

Biological Process:
urea cycle [GO:0000050],
citrulline metabolic process [GO:0000052],
argininosuccinate metabolic process [GO:0000053],
kidney development [GO:0001822],
liver development [GO:0001889],
arginine biosynthetic process [GO:0006526],
aspartate metabolic process [GO:0006531],
acute-phase response [GO:0006953],
midgut development [GO:0007494],
aging [GO:0007568],
response to nutrient [GO:0007584],
circadian rhythm [GO:0007623],
response to zinc ion [GO:0010043],
response to mycotoxin [GO:0010046],
response to estradiol [GO:0032355],
positive regulation of nitric oxide biosynthetic process [GO:0045429],
response to growth hormone [GO:0060416],
diaphragm development [GO:0060539],
cellular response to lipopolysaccharide [GO:0071222],
cellular response to amino acid stimulus [GO:0071230],
cellular response to ammonium ion [GO:0071242],
cellular response to cAMP [GO:0071320],
cellular response to interferon-gamma [GO:0071346],
cellular response to tumor necrosis factor [GO:0071356],
cellular response to glucagon stimulus [GO:0071377],
cellular response to oleic acid [GO:0071400],
cellular response to amine stimulus [GO:0071418],
cellular response to laminar fluid shear stress [GO:0071499],
cellular response to dexamethasone stimulus [GO:0071549],
negative regulation of leukocyte cell-cell adhesion [GO:1903038],
cellular amino acid biosynthetic process [GO:0008652],
response to glucocorticoid [GO:0051384],

Molecular Function:
RNA binding [GO:0003723],
argininosuccinate synthase activity [GO:0004055],
protein binding [GO:0005515],
ATP binding [GO:0005524],
toxic substance binding [GO:0015643],
amino acid binding [GO:0016597],
identical protein binding [GO:0042802],
nucleotide binding [GO:0000166],
ligase activity [GO:0016874],

Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],
mitochondrial outer membrane [GO:0005741],
lysosome [GO:0005764],
endoplasmic reticulum [GO:0005783],
cytosol [GO:0005829],
perikaryon [GO:0043204],
extracellular exosome [GO:0070062],
cell body fiber [GO:0070852],
mitochondrion [GO:0005739],
neuron projection [GO:0043005],
neuronal cell body [GO:0043025],
myelin sheath [GO:0043209],