NEIL2

nei like DNA glycosylase 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF, HCA89 Skin, Lung Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2 Human YES

GO terms:

Biological Process:
base-excision repair [GO:0006284],
nucleotide-excision repair [GO:0006289],
depyrimidination [GO:0045008],
DNA repair [GO:0006281],
cellular response to DNA damage stimulus [GO:0006974],
metabolic process [GO:0008152],

Molecular Function:
damaged DNA binding [GO:0003684],
DNA-(apurinic or apyrimidinic site) lyase activity [GO:0003906],
protein binding [GO:0005515],
microtubule binding [GO:0008017],
zinc ion binding [GO:0008270],
DNA N-glycosylase activity [GO:0019104],
nucleic acid binding [GO:0003676],
DNA binding [GO:0003677],
catalytic activity [GO:0003824],
hydrolase activity [GO:0016787],
hydrolase activity, acting on glycosyl bonds [GO:0016798],
hydrolase activity, hydrolyzing N-glycosyl compounds [GO:0016799],
lyase activity [GO:0016829],
metal ion binding [GO:0046872],

Cellular Component:
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
spindle microtubule [GO:0005876],
intracellular membrane-bounded organelle [GO:0043231],
nucleus [GO:0005634],
microtubule cytoskeleton [GO:0015630],