ACACA

acetyl-CoA carboxylase alpha

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31756344 Liver Mouse NO
31983656 MSC Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
27983949 IMR-90 Human NO
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
tissue homeostasis [GO:0001894],
acetyl-CoA metabolic process [GO:0006084],
fatty acid biosynthetic process [GO:0006633],
carnitine shuttle [GO:0006853],
protein metabolic process [GO:0019538],
positive regulation of cellular metabolic process [GO:0031325],
regulation of cholesterol biosynthetic process [GO:0045540],
fatty-acyl-CoA biosynthetic process [GO:0046949],
protein homotetramerization [GO:0051289],
lipid homeostasis [GO:0055088],
cellular response to prostaglandin E stimulus [GO:0071380],
malonyl-CoA biosynthetic process [GO:2001295],
lipid metabolic process [GO:0006629],
fatty acid metabolic process [GO:0006631],
metabolic process [GO:0008152],
response to organic cyclic compound [GO:0014070],

Molecular Function:
acetyl-CoA carboxylase activity [GO:0003989],
protein binding [GO:0005515],
ATP binding [GO:0005524],
identical protein binding [GO:0042802],
metal ion binding [GO:0046872],
nucleotide binding [GO:0000166],
catalytic activity [GO:0003824],
biotin binding [GO:0009374],
ligase activity [GO:0016874],
kinase binding [GO:0019900],

Cellular Component:
fibrillar center [GO:0001650],
cytosol [GO:0005829],
actin cytoskeleton [GO:0015629],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],