ASPM
assembly factor for spindle microtubules
Link to human orthologLink to mouse ortholog
Search for interactions with genes linked to senescence.
Status in senescence: Down-regulated | ||||
| Pubmed ID | Cell line | Tissue | Source | High-throughput |
| 27323328 | Saos-2,H1299, HT18, MCF7, MDA-MB-231, Li-Fraumeni | Human | YES | |
| 29321003 | Primary bronchial epithelial cells derived from lung | Human | YES | |
| 29548335 | Saos-2 | Human | YES | |
| 30977188 | MSC | Human | YES | |
| 30988157 | IMR-90 | Human | YES | |
| 31945125 | Primary astrocytes derived from brain | Human | YES | |
GO terms:
Biological Process:
neuron migration [GO:0001764],
positive regulation of neuroblast proliferation [GO:0002052],
cell cycle [GO:0007049],
spindle organization [GO:0007051],
spermatogenesis [GO:0007283],
brain development [GO:0007420],
male gonad development [GO:0008584],
forebrain neuroblast division [GO:0021873],
cerebral cortex development [GO:0021987],
negative regulation of neuron differentiation [GO:0045665],
negative regulation of asymmetric cell division [GO:0045769],
oogenesis [GO:0048477],
developmental growth [GO:0048589],
cell division [GO:0051301],
regulation of meiotic cell cycle [GO:0051445],
spindle localization [GO:0051653],
maintenance of centrosome location [GO:0051661],
positive regulation of canonical Wnt signaling pathway [GO:0090263],
spindle assembly involved in meiosis [GO:0090306],
neuronal stem cell population maintenance [GO:0097150],
Molecular Function:
calmodulin binding [GO:0005516],
Cellular Component:
spindle pole [GO:0000922],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
centrosome [GO:0005813],
cytoskeleton [GO:0005856],
microtubule [GO:0005874],
apical plasma membrane [GO:0016324],
midbody [GO:0030496],
microtubule minus-end [GO:0036449],
meiotic spindle [GO:0072687],
mitotic spindle pole [GO:0097431],