NCSTN

nicastrin

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31615473 WI-38, IMR-90, HUVEC, HAEC Human YES

GO terms:

Biological Process:
myeloid cell homeostasis [GO:0002262],
proteolysis [GO:0006508],
membrane protein ectodomain proteolysis [GO:0006509],
dopamine receptor signaling pathway [GO:0007212],
glutamate receptor signaling pathway [GO:0007215],
Notch receptor processing [GO:0007220],
learning or memory [GO:0007611],
protein processing [GO:0016485],
cerebellum development [GO:0021549],
central nervous system myelination [GO:0022010],
adult behavior [GO:0030534],
membrane protein intracellular domain proteolysis [GO:0031293],
beta-amyloid formation [GO:0034205],
Notch receptor processing, ligand-dependent [GO:0035333],
T cell proliferation [GO:0042098],
amyloid precursor protein metabolic process [GO:0042982],
amyloid precursor protein biosynthetic process [GO:0042983],
positive regulation of amyloid precursor protein biosynthetic process [GO:0042986],
amyloid precursor protein catabolic process [GO:0042987],
positive regulation of apoptotic process [GO:0043065],
positive regulation of catalytic activity [GO:0043085],
neutrophil degranulation [GO:0043312],
cellular protein metabolic process [GO:0044267],
ephrin receptor signaling pathway [GO:0048013],
epithelial cell proliferation [GO:0050673],
neuron apoptotic process [GO:0051402],
cellular response to calcium ion [GO:0071277],
regulation of long-term synaptic potentiation [GO:1900271],
short-term synaptic potentiation [GO:1990926],
Notch signaling pathway [GO:0007219],
beta-amyloid metabolic process [GO:0050435],
neuron death [GO:0070997],

Molecular Function:
endopeptidase activity [GO:0004175],
protein binding [GO:0005515],
ATPase binding [GO:0051117],
growth factor receptor binding [GO:0070851],
peptidase activity [GO:0008233],

Cellular Component:
mitochondrion [GO:0005739],
lysosomal membrane [GO:0005765],
early endosome [GO:0005769],
endoplasmic reticulum [GO:0005783],
Golgi apparatus [GO:0005794],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
focal adhesion [GO:0005925],
synaptic vesicle [GO:0008021],
endosome membrane [GO:0010008],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
azurophil granule membrane [GO:0035577],
sarcolemma [GO:0042383],
melanosome [GO:0042470],
extracellular exosome [GO:0070062],
gamma-secretase complex [GO:0070765],
integral component of presynaptic membrane [GO:0099056],
cytoplasm [GO:0005737],
lysosome [GO:0005764],
cytoplasmic vesicle [GO:0031410],
macromolecular complex [GO:0032991],
synapse [GO:0045202],
synaptic membrane [GO:0097060],