ASNS
asparagine synthetase (glutamine-hydrolyzing)
Link to human orthologLink to mouse ortholog
Search for interactions with genes linked to senescence.
Status in senescence: Up-regulated | ||||
| Pubmed ID | Cell line | Tissue | Source | High-throughput |
| 29548335 | Li Fraumeni | Human | YES | |
Status in senescence: Down-regulated | ||||
| Pubmed ID | Cell line | Tissue | Source | High-throughput |
| 29321003 | Primary bronchial epithelial cells derived from lung | Human | YES | |
| 31945125 | Primary astrocytes derived from brain | Human | YES | |
GO terms:
Biological Process:
liver development [GO:0001889],
asparagine biosynthetic process [GO:0006529],
glutamine metabolic process [GO:0006541],
cellular amino acid biosynthetic process [GO:0008652],
response to light stimulus [GO:0009416],
response to mechanical stimulus [GO:0009612],
response to toxic substance [GO:0009636],
response to methotrexate [GO:0031427],
response to follicle-stimulating hormone [GO:0032354],
cellular response to hormone stimulus [GO:0032870],
PERK-mediated unfolded protein response [GO:0036499],
cellular response to glucose starvation [GO:0042149],
negative regulation of apoptotic process [GO:0043066],
response to amino acid [GO:0043200],
positive regulation of mitotic cell cycle [GO:0045931],
L-asparagine biosynthetic process [GO:0070981],
Molecular Function:
asparagine synthase (glutamine-hydrolyzing) activity [GO:0004066],
protein binding [GO:0005515],
ATP binding [GO:0005524],
identical protein binding [GO:0042802],
nucleotide binding [GO:0000166],
ligase activity [GO:0016874],
Cellular Component:
cytosol [GO:0005829],