ASL

argininosuccinate lyase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
urea cycle [GO:0000050],
arginine biosynthetic process via ornithine [GO:0042450],
argininosuccinate metabolic process [GO:0000053],
liver development [GO:0001889],
cellular amino acid metabolic process [GO:0006520],
arginine biosynthetic process [GO:0006526],
locomotory behavior [GO:0007626],
cellular amino acid biosynthetic process [GO:0008652],
post-embryonic development [GO:0009791],
ammonia assimilation cycle [GO:0019676],

Molecular Function:
argininosuccinate lyase activity [GO:0004056],
protein binding [GO:0005515],
identical protein binding [GO:0042802],
catalytic activity [GO:0003824],
lyase activity [GO:0016829],

Cellular Component:
cytoplasm [GO:0005737],
cytosol [GO:0005829],
extracellular exosome [GO:0070062],
nucleus [GO:0005634],
mitochondrial outer membrane [GO:0005741],
endoplasmic reticulum [GO:0005783],
neuronal cell body [GO:0043025],
perikaryon [GO:0043204],
perinuclear region of cytoplasm [GO:0048471],
cell body fiber [GO:0070852],