NCKAP1L

NCK associated protein 1 like

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2 Human YES

GO terms:

Biological Process:
cell morphogenesis [GO:0000902],
B cell homeostasis [GO:0001782],
myeloid cell homeostasis [GO:0002262],
chemotaxis [GO:0006935],
cell migration [GO:0016477],
maintenance of cell polarity [GO:0030011],
cell projection assembly [GO:0030031],
neutrophil chemotaxis [GO:0030593],
positive regulation of actin filament polymerization [GO:0030838],
cortical actin cytoskeleton organization [GO:0030866],
positive regulation of B cell proliferation [GO:0030890],
activation of protein kinase activity [GO:0032147],
negative regulation of interleukin-17 production [GO:0032700],
negative regulation of interleukin-6 production [GO:0032715],
positive regulation of cell adhesion mediated by integrin [GO:0033630],
erythrocyte homeostasis [GO:0034101],
negative regulation of myosin-light-chain-phosphatase activity [GO:0035509],
Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096],
positive regulation of T cell proliferation [GO:0042102],
positive regulation of phosphorylation [GO:0042327],
response to drug [GO:0042493],
T cell homeostasis [GO:0043029],
negative regulation of apoptotic process [GO:0043066],
neutrophil degranulation [GO:0043312],
positive regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043372],
positive regulation of CD8-positive, alpha-beta T cell differentiation [GO:0043378],
positive regulation of GTPase activity [GO:0043547],
positive regulation of B cell differentiation [GO:0045579],
positive regulation of gamma-delta T cell differentiation [GO:0045588],
positive regulation of lymphocyte differentiation [GO:0045621],
positive regulation of erythrocyte differentiation [GO:0045648],
vascular endothelial growth factor receptor signaling pathway [GO:0048010],
neuron projection morphogenesis [GO:0048812],
erythrocyte development [GO:0048821],
B cell receptor signaling pathway [GO:0050853],
positive regulation of phagocytosis, engulfment [GO:0060100],
macromolecular complex assembly [GO:0065003],
actin polymerization-dependent cell motility [GO:0070358],
positive regulation of neutrophil chemotaxis [GO:0090023],

Molecular Function:
GTPase activator activity [GO:0005096],
protein binding [GO:0005515],
protein kinase activator activity [GO:0030295],
macromolecular complex binding [GO:0044877],
Rac GTPase binding [GO:0048365],

Cellular Component:
cytosol [GO:0005829],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
membrane [GO:0016020],
secretory granule membrane [GO:0030667],
SCAR complex [GO:0031209],
extracellular exosome [GO:0070062],
ficolin-1-rich granule membrane [GO:0101003],
cytoplasm [GO:0005737],
integral component of membrane [GO:0016021],