NBN

nibrin

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
24141789 MCF7, MDA-MB-231, ZR-75-1, MEF, NBS1-LBI , HeLa Human, mouse NO
25214013 Primary fibroblasts derived from skin Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
30920150 Primary vascular progenitor cells derived from artery Human YES
31983656 MSC Human YES

GO terms:

Biological Process:
DNA damage checkpoint [GO:0000077],
telomere maintenance [GO:0000723],
double-strand break repair via homologous recombination [GO:0000724],
DNA double-strand break processing [GO:0000729],
blastocyst growth [GO:0001832],
DNA replication [GO:0006260],
double-strand break repair [GO:0006302],
double-strand break repair via nonhomologous end joining [GO:0006303],
cell cycle arrest [GO:0007050],
mitotic cell cycle checkpoint [GO:0007093],
mitotic G2 DNA damage checkpoint [GO:0007095],
cell proliferation [GO:0008283],
viral process [GO:0016032],
telomere capping [GO:0016233],
regulation of DNA-dependent DNA replication initiation [GO:0030174],
DNA damage response, signal transduction by p53 class mediator [GO:0030330],
telomeric 3' overhang formation [GO:0031860],
positive regulation of protein autophosphorylation [GO:0031954],
positive regulation of telomere maintenance [GO:0032206],
DNA duplex unwinding [GO:0032508],
positive regulation of kinase activity [GO:0033674],
signal transduction in response to DNA damage [GO:0042770],
isotype switching [GO:0045190],
neuromuscular process controlling balance [GO:0050885],
meiotic cell cycle [GO:0051321],
t-circle formation [GO:0090656],
intrinsic apoptotic signaling pathway [GO:0097193],
regulation of signal transduction by p53 class mediator [GO:1901796],
negative regulation of telomere capping [GO:1904354],
in utero embryonic development [GO:0001701],
DNA repair [GO:0006281],
cellular response to DNA damage stimulus [GO:0006974],
cell cycle [GO:0007049],
positive regulation of cell proliferation [GO:0008284],
negative regulation of neuron differentiation [GO:0045665],
negative regulation of viral entry into host cell [GO:0046597],
regulation of fibroblast proliferation [GO:0048145],

Molecular Function:
DNA helicase activity [GO:0003678],
damaged DNA binding [GO:0003684],
protein binding [GO:0005515],
transcription factor binding [GO:0008134],
protein N-terminus binding [GO:0047485],

Cellular Component:
nuclear chromosome, telomeric region [GO:0000784],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
replication fork [GO:0005657],
nucleolus [GO:0005730],
cytosol [GO:0005829],
PML body [GO:0016605],
Mre11 complex [GO:0030870],
site of double-strand break [GO:0035861],
nuclear inclusion body [GO:0042405],
chromosome, telomeric region [GO:0000781],
chromosome [GO:0005694],