ASIC1

acid sensing ion channel subunit 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
behavioral fear response [GO:0001662],
response to amphetamine [GO:0001975],
sodium ion transport [GO:0006814],
signal transduction [GO:0007165],
memory [GO:0007613],
associative learning [GO:0008306],
response to pH [GO:0009268],
response to acidic pH [GO:0010447],
ion transmembrane transport [GO:0034220],
sodium ion transmembrane transport [GO:0035725],
regulation of membrane potential [GO:0042391],
negative regulation of neurotransmitter secretion [GO:0046929],
sensory perception of sour taste [GO:0050915],
protein homotrimerization [GO:0070207],
calcium ion transmembrane transport [GO:0070588],
cellular response to pH [GO:0071467],
ion transport [GO:0006811],
cation transport [GO:0006812],
calcium ion transport [GO:0006816],
monovalent inorganic cation transport [GO:0015672],

Molecular Function:
protein binding [GO:0005515],
ligand-gated sodium channel activity [GO:0015280],
ion gated channel activity [GO:0022839],
acid-sensing ion channel activity [GO:0044736],
ion channel activity [GO:0005216],
cation channel activity [GO:0005261],
sodium channel activity [GO:0005272],
monovalent inorganic cation transmembrane transporter activity [GO:0015077],

Cellular Component:
Golgi apparatus [GO:0005794],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
cell surface [GO:0009986],
synapse [GO:0045202],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
dendritic spine [GO:0043197],
dendritic shaft [GO:0043198],