ASCL1

achaete-scute family bHLH transcription factor 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
neuron migration [GO:0001764],
noradrenergic neuron development [GO:0003358],
noradrenergic neuron fate commitment [GO:0003359],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
Notch signaling pathway [GO:0007219],
regulation of mitotic cell cycle [GO:0007346],
neuroblast fate determination [GO:0007400],
neuroblast proliferation [GO:0007405],
sensory organ development [GO:0007423],
heart development [GO:0007507],
response to lithium ion [GO:0010226],
regulation of gene expression [GO:0010468],
oligodendrocyte development [GO:0014003],
spinal cord association neuron differentiation [GO:0021527],
spinal cord oligodendrocyte cell fate specification [GO:0021530],
vestibular nucleus development [GO:0021750],
cerebral cortex GABAergic interneuron differentiation [GO:0021892],
commitment of neuronal cell to specific neuron type in forebrain [GO:0021902],
central nervous system neuron development [GO:0021954],
cerebral cortex development [GO:0021987],
neurogenesis [GO:0022008],
neuron differentiation [GO:0030182],
regulation of epithelial cell differentiation [GO:0030856],
response to retinoic acid [GO:0032526],
negative regulation of apoptotic process [GO:0043066],
positive regulation of neuron apoptotic process [GO:0043525],
negative regulation of neuron differentiation [GO:0045665],
positive regulation of neuron differentiation [GO:0045666],
positive regulation of Notch signaling pathway [GO:0045747],
positive regulation of cell cycle [GO:0045787],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
cell maturation [GO:0048469],
sympathetic nervous system development [GO:0048485],
neuron fate commitment [GO:0048663],
neuron fate specification [GO:0048665],
neuron development [GO:0048666],
regulation of neurogenesis [GO:0050767],
musculoskeletal movement, spinal reflex action [GO:0050883],
response to folic acid [GO:0051593],
subpallium neuron fate commitment [GO:0060163],
regulation of timing of subpallium neuron differentiation [GO:0060165],
olfactory pit development [GO:0060166],
lung epithelial cell differentiation [GO:0060487],
ventral spinal cord interneuron fate commitment [GO:0060579],
lung neuroendocrine cell differentiation [GO:0061100],
stomach neuroendocrine cell differentiation [GO:0061102],
carotid body glomus cell differentiation [GO:0061103],
adrenal chromaffin cell differentiation [GO:0061104],
sympathetic ganglion development [GO:0061549],
response to epidermal growth factor [GO:0070849],
cellular response to magnetism [GO:0071259],
positive regulation of neural precursor cell proliferation [GO:2000179],
multicellular organism development [GO:0007275],
pattern specification process [GO:0007389],
nervous system development [GO:0007399],
regulation of Notch signaling pathway [GO:0008593],
glial cell differentiation [GO:0010001],
spinal cord oligodendrocyte cell differentiation [GO:0021529],
oligodendrocyte cell fate commitment [GO:0021779],
forebrain neuron differentiation [GO:0021879],
cell differentiation [GO:0030154],
regulation of cell proliferation [GO:0042127],
enteric nervous system development [GO:0048484],
parasympathetic nervous system development [GO:0048486],
generation of neurons [GO:0048699],
oligodendrocyte differentiation [GO:0048709],
positive regulation of neurogenesis [GO:0050769],

Molecular Function:
RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977],
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001227],
chromatin binding [GO:0003682],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
protein binding [GO:0005515],
transcription factor binding [GO:0008134],
identical protein binding [GO:0042802],
bHLH transcription factor binding [GO:0043425],
protein dimerization activity [GO:0046983],
E-box binding [GO:0070888],
DNA binding [GO:0003677],
double-stranded DNA binding [GO:0003690],
sequence-specific DNA binding [GO:0043565],

Cellular Component:
nuclear chromatin [GO:0000790],
nucleus [GO:0005634],
neuronal cell body [GO:0043025],
RNA polymerase II transcription factor complex [GO:0090575],