MYCN

MYCN proto-oncogene, bHLH transcription factor

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29022893 HEL, K562 Human NO
30657058 LNCaP Prostate gland Human NO
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
regulation of transcription from RNA polymerase II promoter [GO:0006357],
positive regulation of gene expression [GO:0010628],
negative regulation of gene expression [GO:0010629],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of production of miRNAs involved in gene silencing by miRNA [GO:1903800],
cartilage condensation [GO:0001502],
positive regulation of mesenchymal cell proliferation [GO:0002053],
regulation of transcription, DNA-templated [GO:0006355],
positive regulation of cell proliferation [GO:0008284],
positive regulation of cell death [GO:0010942],
lung development [GO:0030324],
embryonic digit morphogenesis [GO:0042733],
regulation of auditory receptor cell differentiation [GO:0045607],
embryonic skeletal system morphogenesis [GO:0048704],
negative regulation of astrocyte differentiation [GO:0048712],
branching morphogenesis of an epithelial tube [GO:0048754],
negative regulation of reactive oxygen species metabolic process [GO:2000378],

Molecular Function:
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001228],
DNA binding [GO:0003677],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
protein binding [GO:0005515],
kinase binding [GO:0019900],
protein dimerization activity [GO:0046983],

Cellular Component:
chromatin [GO:0000785],
nuclear chromatin [GO:0000790],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
nucleolus [GO:0005730],
host cell nucleus [GO:0042025],