ankyrin repeat and SOCS box containing 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30988157 IMR-90 Human YES
31945054 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
33296652 heart heart Human NO

GO terms:

Biological Process:
ubiquitin-dependent protein catabolic process [GO:0006511],
signal transduction [GO:0007165],
protein ubiquitination [GO:0016567],
intracellular signal transduction [GO:0035556],
skeletal muscle cell differentiation [GO:0035914],
post-translational protein modification [GO:0043687],
protein polyubiquitination [GO:0000209],
myoblast differentiation [GO:0045445],

Molecular Function:
protein binding [GO:0005515],
ubiquitin protein ligase activity [GO:0061630],

Cellular Component:
ubiquitin ligase complex [GO:0000151],
cytosol [GO:0005829],
Cul5-RING ubiquitin ligase complex [GO:0031466],