ArfGAP with SH3 domain, ankyrin repeat and PH domain 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

GO terms:

Biological Process:
cell projection organization [GO:0030030],
positive regulation of GTPase activity [GO:0043547],
cilium assembly [GO:0060271],
negative regulation of dendritic spine development [GO:0061000],
positive regulation of podosome assembly [GO:0071803],
positive regulation of membrane tubulation [GO:1903527],

Molecular Function:
phosphatidylserine binding [GO:0001786],
GTPase activator activity [GO:0005096],
protein binding [GO:0005515],
phosphatidylinositol-4,5-bisphosphate binding [GO:0005546],
phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547],
phosphatidylinositol-3-phosphate binding [GO:0032266],
metal ion binding [GO:0046872],
cadherin binding [GO:0045296],

Cellular Component:
podosome [GO:0002102],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
membrane [GO:0016020],
cell projection membrane [GO:0031253],
dendritic spine [GO:0043197],