ASAH1
N-acylsphingosine amidohydrolase 1
Link to human orthologLink to mouse ortholog
Search for interactions with genes linked to senescence.
Status in senescence: Up-regulated | ||||
| Pubmed ID | Cell line | Tissue | Source | High-throughput |
| 29548335 | Li Fraumeni | Human | YES | |
| 31945125 | Primary astrocytes derived from brain | Human | YES | |
Status in senescence: Down-regulated | ||||
| Pubmed ID | Cell line | Tissue | Source | High-throughput |
| 28785021 | A375 | Human | NO | |
| 32972203 | heartDPI14 vs healthy | nan | Mouse | NO |
GO terms:
Biological Process:
glycosphingolipid metabolic process [GO:0006687],
keratinocyte differentiation [GO:0030216],
neutrophil degranulation [GO:0043312],
sphingosine biosynthetic process [GO:0046512],
ceramide biosynthetic process [GO:0046513],
ceramide catabolic process [GO:0046514],
regulation of steroid biosynthetic process [GO:0050810],
cellular response to tumor necrosis factor [GO:0071356],
lipid metabolic process [GO:0006629],
sphingolipid metabolic process [GO:0006665],
response to organic substance [GO:0010033],
lung development [GO:0030324],
negative regulation of nucleic acid-templated transcription [GO:1903507],
Molecular Function:
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [GO:0016810],
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811],
ceramidase activity [GO:0017040],
transcription corepressor activity [GO:0003714],
hydrolase activity [GO:0016787],
ligand-dependent nuclear receptor binding [GO:0016922],
Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
nucleus [GO:0005634],
lysosome [GO:0005764],
early endosome [GO:0005769],
endoplasmic reticulum [GO:0005783],
lysosomal lumen [GO:0043202],
extracellular exosome [GO:0070062],
tertiary granule lumen [GO:1904724],
ficolin-1-rich granule lumen [GO:1904813],