ARX

aristaless related homeobox

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
neuron migration [GO:0001764],
regulation of transcription, DNA-templated [GO:0006355],
multicellular organism development [GO:0007275],
nervous system development [GO:0007399],
axon guidance [GO:0007411],
positive regulation of gene expression [GO:0010628],
globus pallidus development [GO:0021759],
olfactory bulb development [GO:0021772],
cerebral cortex tangential migration [GO:0021800],
embryonic olfactory bulb interneuron precursor migration [GO:0021831],
cell proliferation in forebrain [GO:0021846],
cerebral cortex GABAergic interneuron migration [GO:0021853],
cell differentiation [GO:0030154],
forebrain development [GO:0030900],
regulation of cell proliferation [GO:0042127],
lipid digestion [GO:0044241],
positive regulation of organ growth [GO:0046622],
autonomic nervous system development [GO:0048483],
enteric nervous system development [GO:0048484],
epithelial cell fate commitment [GO:0072148],

Molecular Function:
RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977],
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001227],
DNA binding [GO:0003677],
chromatin binding [GO:0003682],
sequence-specific DNA binding [GO:0043565],

Cellular Component:
nucleus [GO:0005634],
nuclear chromatin [GO:0000790],