MTHFR

methylenetetrahydrofolate reductase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
21169404 Primary mononuclear cells derived from bone marrow Mouse NO

GO terms:

Biological Process:
response to hypoxia [GO:0001666],
neural tube closure [GO:0001843],
methionine metabolic process [GO:0006555],
one-carbon metabolic process [GO:0006730],
methionine biosynthetic process [GO:0009086],
regulation of histone methylation [GO:0031060],
response to vitamin B2 [GO:0033274],
tetrahydrofolate interconversion [GO:0035999],
response to amino acid [GO:0043200],
S-adenosylmethionine metabolic process [GO:0046500],
folic acid metabolic process [GO:0046655],
homocysteine metabolic process [GO:0050667],
response to folic acid [GO:0051593],
oxidation-reduction process [GO:0055114],
response to interleukin-1 [GO:0070555],
heterochromatin maintenance [GO:0070829],
metabolic process [GO:0008152],
tetrahydrofolate metabolic process [GO:0046653],

Molecular Function:
methylenetetrahydrofolate reductase (NAD(P)H) activity [GO:0004489],
macromolecular complex binding [GO:0044877],
flavin adenine dinucleotide binding [GO:0050660],
NADP binding [GO:0050661],
FAD binding [GO:0071949],
modified amino acid binding [GO:0072341],
catalytic activity [GO:0003824],
oxidoreductase activity [GO:0016491],

Cellular Component:
cytosol [GO:0005829],
synapse [GO:0045202],