MTCL1

microtubule crosslinking factor 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF, HCA692 Skin, Lung Human YES

GO terms:

Biological Process:
microtubule bundle formation [GO:0001578],
regulation of autophagy [GO:0010506],
establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197],
positive regulation of protein targeting to membrane [GO:0090314],
positive regulation of microtubule motor activity [GO:2000576],

Molecular Function:
RNA binding [GO:0003723],
microtubule binding [GO:0008017],
protein homodimerization activity [GO:0042803],
protein binding [GO:0005515],

Cellular Component:
spindle pole [GO:0000922],
extracellular space [GO:0005615],
cytoplasm [GO:0005737],
cytoskeleton [GO:0005856],
apical plasma membrane [GO:0016324],
apicolateral plasma membrane [GO:0016327],
lateral plasma membrane [GO:0016328],
midbody [GO:0030496],
microtubule bundle [GO:0097427],
plasma membrane [GO:0005886],
membrane [GO:0016020],