arrestin beta 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
negative regulation of protein phosphorylation [GO:0001933],
G-protein coupled receptor internalization [GO:0002031],
desensitization of G-protein coupled receptor protein signaling pathway by arrestin [GO:0002032],
positive regulation of receptor internalization [GO:0002092],
transcription from RNA polymerase II promoter [GO:0006366],
transforming growth factor beta receptor signaling pathway [GO:0007179],
G-protein coupled receptor signaling pathway [GO:0007186],
dopamine receptor signaling pathway [GO:0007212],
brain development [GO:0007420],
adult walking behavior [GO:0007628],
positive regulation of gene expression [GO:0010628],
protein transport [GO:0015031],
protein ubiquitination [GO:0016567],
protein deubiquitination [GO:0016579],
platelet activation [GO:0030168],
negative regulation of protein ubiquitination [GO:0031397],
positive regulation of protein ubiquitination [GO:0031398],
receptor internalization [GO:0031623],
negative regulation of NF-kappaB transcription factor activity [GO:0032088],
positive regulation of synaptic transmission, dopaminergic [GO:0032226],
negative regulation of interleukin-1 beta production [GO:0032691],
negative regulation of interleukin-12 production [GO:0032695],
negative regulation of interleukin-6 production [GO:0032715],
negative regulation of tumor necrosis factor production [GO:0032720],
positive regulation of collagen biosynthetic process [GO:0032967],
positive regulation of peptidyl-serine phosphorylation [GO:0033138],
negative regulation of toll-like receptor signaling pathway [GO:0034122],
negative regulation of GTPase activity [GO:0034260],
negative regulation of smooth muscle cell apoptotic process [GO:0034392],
follicle-stimulating hormone signaling pathway [GO:0042699],
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154],
proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161],
negative regulation of neuron apoptotic process [GO:0043524],
negative regulation of natural killer cell mediated cytotoxicity [GO:0045953],
positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731],
detection of temperature stimulus involved in sensory perception of pain [GO:0050965],
positive regulation of protein kinase B signaling [GO:0051897],
negative regulation of protein kinase B signaling [GO:0051898],
positive regulation of calcium ion transport [GO:0051928],
Wnt signaling pathway, planar cell polarity pathway [GO:0060071],
excitatory postsynaptic potential [GO:0060079],
cell chemotaxis [GO:0060326],
regulation of androgen receptor signaling pathway [GO:0060765],
membrane organization [GO:0061024],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
negative regulation of release of cytochrome c from mitochondria [GO:0090201],
positive regulation of epithelial cell apoptotic process [GO:1904037],
positive regulation of DNA biosynthetic process [GO:2000573],
positive regulation of cardiac muscle cell differentiation [GO:2000727],
regulation of protein phosphorylation [GO:0001932],
positive regulation of protein phosphorylation [GO:0001934],
endocytosis [GO:0006897],
signal transduction [GO:0007165],
regulation of G-protein coupled receptor protein signaling pathway [GO:0008277],
negative regulation of signal transduction [GO:0009968],
positive regulation of protein kinase activity [GO:0045860],

Molecular Function:
G-protein coupled receptor binding [GO:0001664],
receptor binding [GO:0005102],
protein binding [GO:0005515],
enzyme binding [GO:0019899],
protein domain specific binding [GO:0019904],
ubiquitin protein ligase binding [GO:0031625],
alpha-1A adrenergic receptor binding [GO:0031691],
alpha-1B adrenergic receptor binding [GO:0031692],
angiotensin receptor binding [GO:0031701],
type 1 angiotensin receptor binding [GO:0031702],
D1 dopamine receptor binding [GO:0031748],
follicle-stimulating hormone receptor binding [GO:0031762],
type 2A serotonin receptor binding [GO:0031826],
platelet activating factor receptor binding [GO:0031859],
identical protein binding [GO:0042802],
protein kinase B binding [GO:0043422],
macromolecular complex binding [GO:0044877],
mitogen-activated protein kinase binding [GO:0051019],
binding, bridging [GO:0060090],
14-3-3 protein binding [GO:0071889],
arrestin family protein binding [GO:1990763],

Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],
endosome [GO:0005768],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
clathrin-coated pit [GO:0005905],
postsynaptic density [GO:0014069],
basolateral plasma membrane [GO:0016323],
endocytic vesicle [GO:0030139],
cytoplasmic vesicle [GO:0031410],
dendritic spine [GO:0043197],
intracellular membrane-bounded organelle [GO:0043231],
postsynaptic membrane [GO:0045211],
intracellular [GO:0005622],
membrane [GO:0016020],