ARRB1

arrestin beta 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2, Li-Fraumeni Human YES
30988157 IMR-90 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
28425985 Primary cells derived from bone marron Human NO

GO terms:

Biological Process:
activation of MAPK activity [GO:0000187],
positive regulation of protein phosphorylation [GO:0001934],
G-protein coupled receptor internalization [GO:0002031],
positive regulation of receptor internalization [GO:0002092],
transcription from RNA polymerase II promoter [GO:0006366],
ubiquitin-dependent protein catabolic process [GO:0006511],
apoptotic process [GO:0006915],
G-protein coupled receptor signaling pathway [GO:0007186],
phototransduction [GO:0007602],
positive regulation of cell proliferation [GO:0008284],
protein transport [GO:0015031],
protein ubiquitination [GO:0016567],
histone acetylation [GO:0016573],
platelet activation [GO:0030168],
negative regulation of protein ubiquitination [GO:0031397],
positive regulation of protein ubiquitination [GO:0031398],
negative regulation of NF-kappaB transcription factor activity [GO:0032088],
positive regulation of protein binding [GO:0032092],
negative regulation of interleukin-6 production [GO:0032715],
negative regulation of interleukin-8 production [GO:0032717],
positive regulation of peptidyl-serine phosphorylation [GO:0033138],
negative regulation of GTPase activity [GO:0034260],
positive regulation of smooth muscle cell apoptotic process [GO:0034393],
positive regulation of Rho protein signal transduction [GO:0035025],
positive regulation of histone acetylation [GO:0035066],
positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774],
response to drug [GO:0042493],
follicle-stimulating hormone signaling pathway [GO:0042699],
stress fiber assembly [GO:0043149],
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154],
proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161],
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280],
negative regulation of neuron apoptotic process [GO:0043524],
positive regulation of GTPase activity [GO:0043547],
negative regulation of Notch signaling pathway [GO:0045746],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
membrane organization [GO:0061024],
negative regulation of ERK1 and ERK2 cascade [GO:0070373],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
positive regulation of histone H4 acetylation [GO:0090240],
negative regulation of protein phosphorylation [GO:0001933],
endocytosis [GO:0006897],
signal transduction [GO:0007165],
regulation of G-protein coupled receptor protein signaling pathway [GO:0008277],
negative regulation of signal transduction [GO:0009968],
regulation of apoptotic process [GO:0042981],
negative regulation of apoptotic process [GO:0043066],

Molecular Function:
transcription regulatory region sequence-specific DNA binding [GO:0000976],
G-protein coupled receptor binding [GO:0001664],
histone acetyltransferase activity [GO:0004402],
enzyme inhibitor activity [GO:0004857],
GTPase activator activity [GO:0005096],
insulin-like growth factor receptor binding [GO:0005159],
protein binding [GO:0005515],
transcription factor binding [GO:0008134],
estrogen receptor binding [GO:0030331],
mitogen-activated protein kinase kinase binding [GO:0031434],
ubiquitin protein ligase binding [GO:0031625],
alpha-1A adrenergic receptor binding [GO:0031691],
alpha-1B adrenergic receptor binding [GO:0031692],
angiotensin receptor binding [GO:0031701],
follicle-stimulating hormone receptor binding [GO:0031762],
V2 vasopressin receptor binding [GO:0031896],
AP-2 adaptor complex binding [GO:0035612],
clathrin adaptor activity [GO:0035615],
cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027],
ion channel binding [GO:0044325],
protein phosphorylated amino acid binding [GO:0045309],
arrestin family protein binding [GO:1990763],
receptor binding [GO:0005102],
enzyme binding [GO:0019899],
clathrin binding [GO:0030276],
phosphoprotein binding [GO:0051219],

Cellular Component:
Golgi membrane [GO:0000139],
chromatin [GO:0000785],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
lysosomal membrane [GO:0005765],
endosome [GO:0005768],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
clathrin-coated pit [GO:0005905],
postsynaptic density [GO:0014069],
basolateral plasma membrane [GO:0016323],
nuclear body [GO:0016604],
cytoplasmic vesicle membrane [GO:0030659],
pseudopodium [GO:0031143],
cytoplasmic vesicle [GO:0031410],
dendritic spine [GO:0043197],
postsynaptic membrane [GO:0045211],
intracellular [GO:0005622],
membrane [GO:0016020],
cell projection [GO:0042995],