actin related protein 2/3 complex subunit 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
positive regulation of lamellipodium assembly [GO:0010592],
actin filament polymerization [GO:0030041],
Arp2/3 complex-mediated actin nucleation [GO:0034314],
Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096],
ephrin receptor signaling pathway [GO:0048013],
membrane organization [GO:0061024],
actin polymerization-dependent cell motility [GO:0070358],
positive regulation of substrate adhesion-dependent cell spreading [GO:1900026],
positive regulation of smooth muscle cell migration [GO:0014911],
regulation of actin filament polymerization [GO:0030833],
positive regulation of actin filament polymerization [GO:0030838],
cellular response to platelet-derived growth factor stimulus [GO:0036120],
positive regulation of filopodium assembly [GO:0051491],
protein kinase C signaling [GO:0070528],
cellular response to epidermal growth factor stimulus [GO:0071364],
positive regulation of podosome assembly [GO:0071803],
cellular response to rapamycin [GO:0072752],
positive regulation of protein targeting to membrane [GO:0090314],
positive regulation of actin cytoskeleton reorganization [GO:2000251],
positive regulation of barbed-end actin filament capping [GO:2000814],

Molecular Function:
structural constituent of cytoskeleton [GO:0005200],
protein binding [GO:0005515],
actin filament binding [GO:0051015],
actin binding [GO:0003779],
glutamate receptor binding [GO:0035254],
macromolecular complex binding [GO:0044877],
ATPase binding [GO:0051117],

Cellular Component:
nucleus [GO:0005634],
endosome [GO:0005768],
cytosol [GO:0005829],
Arp2/3 protein complex [GO:0005885],
focal adhesion [GO:0005925],
actin cytoskeleton [GO:0015629],
lamellipodium [GO:0030027],
site of double-strand break [GO:0035861],
muscle cell projection membrane [GO:0036195],
neuron projection [GO:0043005],
extracellular exosome [GO:0070062],
glutamatergic synapse [GO:0098978],
cytoplasm [GO:0005737],
cytoskeleton [GO:0005856],
plasma membrane [GO:0005886],
cell surface [GO:0009986],
cell junction [GO:0030054],
secretory granule [GO:0030141],
growth cone [GO:0030426],
cell leading edge [GO:0031252],
filamentous actin [GO:0031941],
ruffle membrane [GO:0032587],
cell projection [GO:0042995],
dendritic spine [GO:0043197],
dendritic shaft [GO:0043198],
perikaryon [GO:0043204],
axon terminus [GO:0043679],
synapse [GO:0045202],
invadopodium [GO:0071437],
apical dendrite [GO:0097440],