MMP9

matrix metallopeptidase 9

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
21855630 491, 531 Human NO
29548335 Saos-2 Human YES
30508396 Primary cells derived from muscle Human NO
30716534 Primary cells derived from nucleus pulposus Human NO
30988157 IMR-90 Human YES
31080015 Primary stem cells derived from endometrium Human NO
31183403 IMR-90 Human YES
31424120 Primary cytotrophoblast cells derived from placenta Placenta Mouse NO
31581517 Primary cells derived form heart Pig NO
31602539 HDF Human NO
31878008 Heart Human NO
31945054 IMR-90 Human YES
31653055 MCF 10A, MCF7 Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
31542391 Plasma Human NO

GO terms:

Biological Process:
skeletal system development [GO:0001501],
positive regulation of protein phosphorylation [GO:0001934],
proteolysis [GO:0006508],
embryo implantation [GO:0007566],
cytokine-mediated signaling pathway [GO:0019221],
extracellular matrix disassembly [GO:0022617],
extracellular matrix organization [GO:0030198],
macrophage differentiation [GO:0030225],
positive regulation of cell migration [GO:0030335],
collagen catabolic process [GO:0030574],
cellular response to reactive oxygen species [GO:0034614],
endodermal cell differentiation [GO:0035987],
negative regulation of apoptotic process [GO:0043066],
neutrophil degranulation [GO:0043312],
positive regulation of DNA binding [GO:0043388],
positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742],
ephrin receptor signaling pathway [GO:0048013],
positive regulation of keratinocyte migration [GO:0051549],
cellular response to cadmium ion [GO:0071276],
positive regulation of release of cytochrome c from mitochondria [GO:0090200],
positive regulation of receptor binding [GO:1900122],
response to beta-amyloid [GO:1904645],
positive regulation of vascular smooth muscle cell proliferation [GO:1904707],
negative regulation of epithelial cell differentiation involved in kidney development [GO:2000697],
negative regulation of intrinsic apoptotic signaling pathway [GO:2001243],
negative regulation of cation channel activity [GO:2001258],
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:2001268],
positive regulation of leukocyte migration [GO:0002687],
response to oxidative stress [GO:0006979],
heart development [GO:0007507],
aging [GO:0007568],
transformation of host cell by virus [GO:0019087],
positive regulation of synaptic plasticity [GO:0031915],
response to drug [GO:0042493],
positive regulation of apoptotic process [GO:0043065],
positive regulation of angiogenesis [GO:0045766],
negative regulation of fibroblast proliferation [GO:0048147],
tissue remodeling [GO:0048771],
cellular response to cell-matrix adhesion [GO:0071460],

Molecular Function:
endopeptidase activity [GO:0004175],
metalloendopeptidase activity [GO:0004222],
serine-type endopeptidase activity [GO:0004252],
protein binding [GO:0005515],
collagen binding [GO:0005518],
peptidase activity [GO:0008233],
metallopeptidase activity [GO:0008237],
zinc ion binding [GO:0008270],
identical protein binding [GO:0042802],
fibronectin binding [GO:0001968],
hydrolase activity [GO:0016787],
macromolecular complex binding [GO:0044877],
metal ion binding [GO:0046872],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
extracellular exosome [GO:0070062],
tertiary granule lumen [GO:1904724],
ficolin-1-rich granule lumen [GO:1904813],
extracellular matrix [GO:0031012],
macromolecular complex [GO:0032991],