matrix metallopeptidase 8

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30988157 IMR-90 Human YES
31184599 WI-38, IMR-90, HCA-2 Human YES
31945054 IMR-90 Human YES

GO terms:

Biological Process:
proteolysis [GO:0006508],
positive regulation of gene expression [GO:0010628],
negative regulation of gene expression [GO:0010629],
extracellular matrix disassembly [GO:0022617],
extracellular matrix organization [GO:0030198],
collagen catabolic process [GO:0030574],
negative regulation of interleukin-10 production [GO:0032693],
positive regulation of interleukin-6 production [GO:0032755],
endodermal cell differentiation [GO:0035987],
neutrophil degranulation [GO:0043312],
positive regulation of DNA binding [GO:0043388],
positive regulation of MAPK cascade [GO:0043410],
positive regulation of nitric oxide biosynthetic process [GO:0045429],
positive regulation of JNK cascade [GO:0046330],
positive regulation of NIK/NF-kappaB signaling [GO:1901224],
positive regulation of reactive oxygen species biosynthetic process [GO:1903428],
regulation of microglial cell activation [GO:1903978],
positive regulation of microglial cell activation [GO:1903980],
positive regulation of tumor necrosis factor secretion [GO:1904469],

Molecular Function:
endopeptidase activity [GO:0004175],
metalloendopeptidase activity [GO:0004222],
serine-type endopeptidase activity [GO:0004252],
peptidase activity [GO:0008233],
zinc ion binding [GO:0008270],
calcium ion binding [GO:0005509],
metallopeptidase activity [GO:0008237],
hydrolase activity [GO:0016787],
metal ion binding [GO:0046872],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
specific granule lumen [GO:0035580],
tertiary granule lumen [GO:1904724],
extracellular matrix [GO:0031012],