MMP7

matrix metallopeptidase 7

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30988157 IMR-90 Human YES
31183403 IMR-90 Human YES
31184599 WI-38, IMR-90, HCA-2 Human YES
31945054 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
18364512 Primary mammary epithelial cells derived from breast Human NO
19682489 Primary mammary epithelial cells derived from breast Human NO
31653055 AGS, MCF 10A, MCF7 Human NO

GO terms:

Biological Process:
proteolysis [GO:0006508],
aging [GO:0007568],
extracellular matrix disassembly [GO:0022617],
extracellular matrix organization [GO:0030198],
collagen catabolic process [GO:0030574],
response to nutrient levels [GO:0031667],
estrous cycle [GO:0044849],
maternal process involved in female pregnancy [GO:0060135],
cellular response to mechanical stimulus [GO:0071260],
antibacterial peptide secretion [GO:0002779],
antibacterial peptide biosynthetic process [GO:0002780],
regulation of cell proliferation [GO:0042127],
response to drug [GO:0042493],
defense response to bacterium [GO:0042742],
defense response to Gram-negative bacterium [GO:0050829],
defense response to Gram-positive bacterium [GO:0050830],

Molecular Function:
endopeptidase activity [GO:0004175],
metalloendopeptidase activity [GO:0004222],
serine-type endopeptidase activity [GO:0004252],
protein binding [GO:0005515],
heparin binding [GO:0008201],
metallopeptidase activity [GO:0008237],
zinc ion binding [GO:0008270],
peptidase activity [GO:0008233],
hydrolase activity [GO:0016787],
metal ion binding [GO:0046872],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
cell surface [GO:0009986],
extracellular matrix [GO:0031012],
extracellular exosome [GO:0070062],