ABR activator of RhoGEF and GTPase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES
31983656 MSC Human YES

GO terms:

Biological Process:
negative regulation of cellular extravasation [GO:0002692],
G-protein coupled receptor signaling pathway [GO:0007186],
small GTPase mediated signal transduction [GO:0007264],
brain development [GO:0007420],
actin cytoskeleton organization [GO:0030036],
response to lipopolysaccharide [GO:0032496],
inner ear morphogenesis [GO:0042472],
positive regulation of apoptotic process [GO:0043065],
regulation of vascular permeability [GO:0043114],
negative regulation of neutrophil degranulation [GO:0043314],
negative regulation of inflammatory response [GO:0050728],
positive regulation of phagocytosis [GO:0050766],
modulation of synaptic transmission [GO:0050804],
neuromuscular process controlling balance [GO:0050885],
regulation of small GTPase mediated signal transduction [GO:0051056],
negative regulation of blood vessel remodeling [GO:0060313],
activation of GTPase activity [GO:0090630],
signal transduction [GO:0007165],
negative regulation of cell migration [GO:0030336],
regulation of Rho protein signal transduction [GO:0035023],
intracellular signal transduction [GO:0035556],
positive regulation of GTPase activity [GO:0043547],

Molecular Function:
guanyl-nucleotide exchange factor activity [GO:0005085],
GTPase activator activity [GO:0005096],
protein binding [GO:0005515],
Rho guanyl-nucleotide exchange factor activity [GO:0005089],

Cellular Component:
cytosol [GO:0005829],
plasma membrane [GO:0005886],
membrane [GO:0016020],
axon [GO:0030424],
dendritic spine [GO:0043197],
glutamatergic synapse [GO:0098978],
cell junction [GO:0030054],
cell projection [GO:0042995],
synapse [GO:0045202],