matrix metallopeptidase 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30508396 Primary cells derived from muscle Human NO
30716534 Primary cells derived from nucleus pulposus Human NO
30892080 Primary epithelial cells derived from lung Mouse NO
31080015 Primary stem cells derived from endometrium Human NO
31183403 IMR-90 Human YES
31242426 HFF-2  Human YES
31424120 Primary cytotrophoblast cells derived from placenta Placenta Mouse NO
31581517 Primary cells derived form heart Pig NO
31945054 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31542391 Plasma Human NO

GO terms:

Biological Process:
angiogenesis [GO:0001525],
response to hypoxia [GO:0001666],
blood vessel maturation [GO:0001955],
intramembranous ossification [GO:0001957],
proteolysis [GO:0006508],
embryo implantation [GO:0007566],
cytokine-mediated signaling pathway [GO:0019221],
extracellular matrix disassembly [GO:0022617],
extracellular matrix organization [GO:0030198],
collagen catabolic process [GO:0030574],
cellular response to reactive oxygen species [GO:0034614],
endodermal cell differentiation [GO:0035987],
cellular protein metabolic process [GO:0044267],
ephrin receptor signaling pathway [GO:0048013],
tissue remodeling [GO:0048771],
face morphogenesis [GO:0060325],
bone trabecula formation [GO:0060346],
cellular response to amino acid stimulus [GO:0071230],
response to beta-amyloid [GO:1904645],
positive regulation of vascular smooth muscle cell proliferation [GO:1904707],
ovarian follicle development [GO:0001541],
response to oxidative stress [GO:0006979],
negative regulation of cell adhesion [GO:0007162],
heart development [GO:0007507],
aging [GO:0007568],
response to mechanical stimulus [GO:0009612],
peripheral nervous system axon regeneration [GO:0014012],
cell migration [GO:0016477],
positive regulation of cell migration [GO:0030335],
response to drug [GO:0042493],
response to hydrogen peroxide [GO:0042542],
positive regulation of apoptotic process [GO:0043065],
response to estrogen [GO:0043627],
positive regulation of innate immune response [GO:0045089],
negative regulation of vasoconstriction [GO:0045906],
positive regulation of smooth muscle cell proliferation [GO:0048661],
skeletal system morphogenesis [GO:0048705],
prostate gland epithelium morphogenesis [GO:0060740],
cellular response to estradiol stimulus [GO:0071392],

Molecular Function:
endopeptidase activity [GO:0004175],
metalloendopeptidase activity [GO:0004222],
serine-type endopeptidase activity [GO:0004252],
protein binding [GO:0005515],
metallopeptidase activity [GO:0008237],
zinc ion binding [GO:0008270],
fibronectin binding [GO:0001968],
peptidase activity [GO:0008233],
hydrolase activity [GO:0016787],
metal ion binding [GO:0046872],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
nucleus [GO:0005634],
mitochondrion [GO:0005739],
plasma membrane [GO:0005886],
sarcomere [GO:0030017],
cytoplasm [GO:0005737],
membrane [GO:0016020],
extracellular matrix [GO:0031012],