matrix metallopeptidase 16

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31148378 MRC-5 Human YES
31242426 HFF-2  Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
skeletal system development [GO:0001501],
endochondral ossification [GO:0001958],
proteolysis [GO:0006508],
protein processing [GO:0016485],
protein metabolic process [GO:0019538],
extracellular matrix disassembly [GO:0022617],
extracellular matrix organization [GO:0030198],
collagen catabolic process [GO:0030574],
chondrocyte proliferation [GO:0035988],
positive regulation of catalytic activity [GO:0043085],
embryonic cranial skeleton morphogenesis [GO:0048701],
craniofacial suture morphogenesis [GO:0097094],
ossification [GO:0001503],
bone development [GO:0060348],

Molecular Function:
metalloendopeptidase activity [GO:0004222],
enzyme activator activity [GO:0008047],
zinc ion binding [GO:0008270],
metalloaminopeptidase activity [GO:0070006],
peptidase activity [GO:0008233],
metallopeptidase activity [GO:0008237],
hydrolase activity [GO:0016787],
metal ion binding [GO:0046872],

Cellular Component:
Golgi lumen [GO:0005796],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
cell surface [GO:0009986],
extracellular matrix [GO:0031012],
membrane [GO:0016020],
integral component of membrane [GO:0016021],